Evidence map›Paper›PMID 40445123›Full record

Trial reportHuman vaccines & immunotherapeutics2025

Comparative immune response of Typbar TCV® (typhoid conjugate vaccine) in extremes of age: An Indian experience.

Krishna Mohan Vadrevu, Siddharth Reddy Chiteti, Raju Dugyala, Vinay Kumar Aileni, Akhila Kunta, Badri Narayan Patnaik, Raches Ella

Abstract readClinical Trial, Phase IIIClinical Trial, Phase IVComparative Study
In one paragraph

Trial report in Human vaccines & immunotherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Krishna Mohan VadrevuBharat Biotech International Ltd, Hyderabad, India.
Siddharth Reddy ChitetiBharat Biotech International Ltd, Hyderabad, India.
Raju DugyalaBharat Biotech International Ltd, Hyderabad, India.
Vinay Kumar AileniBharat Biotech International Ltd, Hyderabad, India.
Akhila KuntaBharat Biotech International Ltd, Hyderabad, India.
Badri Narayan PatnaikBharat Biotech International Ltd, Hyderabad, India.
Raches EllaBharat Biotech International Ltd, Hyderabad, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Typhoid fever is a significant health concern in low- and middle-income countries, with millions of cases and thousands of deaths each year. Typhoid Conjugate Vaccines, such as Typbar TCV®, have been developed to provide longer-lasting protection for young children. This publication includes the readouts from two different studies in Children and elderly: a Comparator Study and Age Extension Study. In the first study, children are included, whereas the latter study also includes elderly subjects. A total of 340 children were enrolled, and a subset received a booster dose of Typbar TCV®, 180 days later. Results established that Typbar TCV® induced significantly higher antibody titer compared to Typhim Vi on days 28 and 90 (

Indexed as

Antibodies, BacterialTyphoid FeverTyphoid-Paratyphoid VaccinesAdolescentAdultAgedAged, 80 and overAge FactorsChildChild, PreschoolFemaleHumansImmunization, SecondaryImmunoglobulin GIndiaInfantAntibodies, BacterialImmunoglobulin GTyphoid-Paratyphoid VaccinesVaccines, ConjugateImmunogenicitysalmonella TyphiTypbar TCV®Typhim Vityphoidtyphoid conjugate vaccine

Identifiers

PMID40445123
PMCPMC12128665

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.