ArticleJournal of virology2025
Revisiting the early event of African swine fever virus DNA replication.
Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Epigallocatechin gallate (EGCG) inhibits African swine fever virus replication by targeting key viral proteins and regulating host lipid metabolism.Emerging microbes & infections · 2026Article
- Multiple directed mutagenesis reduces enzymatic activity and antibody recognition of the African Swine Fever Virus E2 ubiquitin-conjugating protein (ASFV-pI215L).Emerging microbes & infections · 2026Article
- Article
- Infection cycles of viruses of the phylum Nucleocytoviricota.Nature reviews. Microbiology · 2026Review
- ASFV pA137R protein triggers inflammatory response by inducing NF-κB signaling pathway and facilitating NLRP3 inflammasome assembly.Virologica Sinica · 2026Article
- Indirect ELISA Based on ASFV Polymerase Three Subunits for Serological Monitoring of African Swine Fever Antibodies.Veterinary sciences · 2026Article
- Structural and Functional Analysis of ASFV pI73R Reveals GNB1 Binding and Host Gene Modulation.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
As a member of nucleocytoplasmic large DNA viruses, African swine fever virus (ASFV) has been proposed to include an intriguing nuclear stage for DNA replication. In this report, we revisited this early event by using the ASFV type II strain HN09 as a model organism. Our studies began with dissecting the early stages of the ASFV life cycle via analyses by viral growth kinetics, electron microscopy, and quantitative PCR (qPCR). We showed that the single replication cycle lasted about 9 h, with the initial early mRNA transcription taking place around 0.5 h upon virus incubation with host cells, a timing that is much earlier than previously found; the viral DNA replication occurred around 4-5 hours post-infection (hpi), coinciding with the formation of early viral factory (VF), followed by virion morphogenesis at 6-9 hpi. The time-course tracking of viral genomic and newly synthesized DNA via EdU (5-ethynyl-2-deoxyuridine) labeling and DNAscope
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.