Evidence map›Paper›PMID 40444956›Full record

ArticlemSphere2025

Defining neuronal responses to the neurotropic parasite

Hannah J Johnson, Joshua A Kochanowsky, Sambamurthy Chandrasekaran, Christopher A Hunter, Daniel P Beiting, Anita A Koshy

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Movement Disorders in Toxoplasmosis: A Systematic Review.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Hannah J JohnsonNeuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0001-5942-9483
Joshua A KochanowskyBIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Sambamurthy ChandrasekaranBIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Christopher A HunterDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-3092-1428
Daniel P BeitingDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2865-4589
Anita A KoshyNeuroscience Graduate Interdisciplinary Program, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0001-8705-3233

Funding

Neuronal Latency and ToxoplasmaR01AI157247 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CHRISTOPHER A HUNTER, Anita Koshy · 2020 to 2026
$4.7M
NIAID NIH HHS R01 AI157247NIH HHS R01 AI157247
6 · The paper itself

Abstract

A select group of pathogens infects neurons in the brain. Prior dogma held that neurons were "defenseless" against infecting microbes, but many studies suggest that neurons can mount anti-microbial defenses. However, a knowledge gap in understanding how neurons respond

Indexed as

NeuronsToxoplasmaAnimalsCells, CulturedCytokinesMiceWest Nile virusZika VirusCytokinescentral nervous system infectionshost responseneuronsRNA-seqT. gondiiToxoplasma gondiitranscriptomics

Identifiers

PMID40444956
PMCPMC12188731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.