Evidence map›Paper›PMID 40444818›Full record

Trial reportJournal of periodontology2025

Randomized clinical trial evaluating kinetic benefits of desensitizing agents: Magnitude, onset, and stability of relief.

Aaron R Biesbrock, Tao He, Yuanshu Zou, Julie M Grender, Pejmon Amini, Paul A Sagel, Andrew Groth, Malgorzata Klukowska

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03965039 (A Randomized Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03965039 nacompletednot on this map

A Randomized Clinical Study to Assess the Effects of Various Dentifrice Technologies on Dentinal Hypersensitivity

TypeinterventionalSponsorProcter and GambleRan2019 to 2019Enrolled120ConditionsDentin HypersensitivityArmsDipotassium oxalate toothpaste, Stannous fluoride toothpaste, Potassium nitrate toothpaste, Sodium monofluorophosphate toothpaste
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aaron R BiesbrockGlobal Oral Care Research & Development, The Procter & Gamble Company, Mason, Ohio, USA.
Tao HeGlobal Oral Care Research & Development, The Procter & Gamble Company, Mason, Ohio, USA.
Yuanshu ZouGlobal Oral Care Research & Development, The Procter & Gamble Company, Mason, Ohio, USA.
Julie M GrenderGlobal Oral Care Research & Development, The Procter & Gamble Company, Mason, Ohio, USA.
Pejmon AminiSilverstone Research Group, Las Vegas, Nevada, USA.
Paul A SagelGlobal Oral Care Research & Development, The Procter & Gamble Company, Mason, Ohio, USA.
Andrew GrothGlobal Oral Care Research & Development, The Procter & Gamble Company, Mason, Ohio, USA.
Malgorzata KlukowskaGlobal Oral Care Research & Development, The Procter & Gamble Company, Mason, Ohio, USA.

Funding

Procter & Gamble Company
6 · The paper itself

Abstract

backgroundDentin hypersensitivity (DH) is common, particularly among periodontal patients. This trial evaluated magnitude of desensitizing benefit, onset of action, and complete relief of three dentifrices with distinct desensitizing technologies.

methodsHealthy adults with DH were enrolled and randomized to one of four dentifrices in this randomized, controlled, double-blind trial: marketed potassium nitrate (KNO

resultsA total of 120 participants were randomized to treatment, and 118 completed the study. Thermal challenge (Schiff): All treatments provided greater relief than NC at all timepoints (p ≤ 0.004). The SnF

conclusionSnF

trial registrationNCT03965039 PLAIN LANGUAGE SUMMARY: This study tested four toothpastes for sensitivity relief, including speed and completeness of relief, among approximately 120 adults with sensitive teeth. They were randomly assigned to use one of four toothpastes: commercial toothpaste with potassium nitrate, commercial toothpaste with stannous fluoride, experimental toothpaste with oxalate, or standard fluoride toothpaste (control) with no antisensitivity ingredient. Participants used their toothpaste twice daily for 8 weeks, and then everyone used the control toothpaste for 3 weeks. Sensitivity was measured at the beginning of the study, after 3 days, and after 2, 4, 8, and 11 weeks by blowing cold air on sensitive teeth and moving a probe across the sensitive area (tactile assessment). The potassium nitrate, stannous fluoride, and oxalate toothpastes reduced sensitivity better than the control toothpaste at all times, except potassium nitrate toothpaste at Day 3 for tactile sensitivity. Stannous fluoride toothpaste reduced cold air sensitivity better than potassium nitrate toothpaste at Week 2 and across all times combined. More participants showed complete relief from cold air sensitivity for stannous fluoride toothpaste than potassium nitrate toothpaste through Week 8. Stannous fluoride toothpaste had greater improvements in tactile sensitivity versus potassium nitrate toothpaste at Day 3. Overall, stannous fluoride toothpaste was superior at relieving sensitivity.

Indexed as

DentifricesDentin Desensitizing AgentsDentin SensitivityAdultDouble-Blind MethodFemaleFluoridesFollow-Up StudiesHumansMaleMiddle AgedNitratesOxalatesPhosphatesPotassium CompoundsTin FluoridesDentifricesDentin Desensitizing AgentsFluoridesfluorophosphateNitratesOxalatesPhosphatesPotassium Compoundspotassium nitrateTin Fluoridesdentinal fluiddentin desensitizing agentsoral hygieneoxalatespotassium nitratestannous fluoride

Identifiers

PMID40444818
PMCPMC12819361

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.