Evidence map›Paper›PMID 40444645›Full record

ArticleAustralian endodontic journal : the journal of the Australian Society of Endodontology Inc2025

Aggressive Neoplasms That Mimic Chronic Endodontic Lesions: A Multi-Institutional Case Series.

Natália Gonçalves Macedo, Fernanda Geraldo Pappen, Bernardo da Fonseca Orcina, Gustavo Mascarenhas, Jean Nunes Dos Santos, Paulo Sérgio da Silva Santos, Carolina Clasen Vieira, Alexandre Simões Garcia, Alini Cardoso Soares, Lauren Frenzel Schuch and 2 more

Abstract readMulticenter Study
In one paragraph

Article in Australian endodontic journal : the journal of the Australian Society of Endodontology Inc, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Natália Gonçalves MacedoDiagnostic Center for Oral Diseases, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0003-3621-8557
Fernanda Geraldo PappenDepartment of Clinical Semiology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0002-8483-455X
Bernardo da Fonseca OrcinaDiagnostic Center for Oral Diseases, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0003-3367-483X
Gustavo MascarenhasPrivate Practitioner, Salvador, Bahia, Brazil.ORCID https://orcid.org/0000-0002-5957-9024
Jean Nunes Dos SantosDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.ORCID https://orcid.org/0000-0001-7225-5879
Paulo Sérgio da Silva SantosDepartment of Surgery, Stomatology, Pathology and Radiology-Bauru School of Dentistry of University of São Paulo, Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0003-1280-0817
Carolina Clasen VieiraDiagnostic Center for Oral Diseases, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0003-4429-4760
Alexandre Simões GarciaDepartment of Surgery, Stomatology, Pathology and Radiology-Bauru School of Dentistry of University of São Paulo, Bauru, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-7616-7948
Alini Cardoso SoaresDiagnostic Center for Oral Diseases, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0001-6445-0658
Lauren Frenzel SchuchMolecular Pathology Area, School of Dentistry, Universidad de la República-UDELAR, Montevideo, Uruguay.ORCID https://orcid.org/0000-0002-0993-936X
Ana Paula Neutzling GomesDiagnostic Center for Oral Diseases, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0003-2214-5246
Ana Carolina Uchoa VasconcelosDiagnostic Center for Oral Diseases, School of Dentistry, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.ORCID https://orcid.org/0000-0001-6560-9536

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to report sociodemographic, clinicopathologic and radiological features of 12 cases of aggressive neoplasms that were clinically diagnosed as chronic endodontic lesions. The series comprised seven females (58.33%) and five males (41.67%), with a mean age of 48.9 ± 19.19 years (range: 16-75 years). In six cases (50%), the posterior maxillary region was involved. Internal appearance was radiolucent density (n = 12/100%). Eleven cases (91.67%) exhibited well-defined borders, while one (8.33%) showed ill-defined borders. Histopathologic diagnoses included metastasis (n = 4/33.33%), squamous cell carcinoma (n = 3/25%), mucoepidermoid carcinoma (n = 2/16.68%), acinic cell carcinoma (n = 1/8.33%), Ewing's sarcoma (n = 1/8.33%) and Langerhans cell histiocytosis (n = 1/8.33%). Survival status was retrieved for three patients (25.00%), all of whom were alive at the time of reporting. This study identified seven distinct histological types of aggressive neoplasms that mimic chronic periapical lesions. Given that such lesions often lack clinical or radiological signs of aggressive behaviour, it is imperative that all excised tissue undergo histopathological examination.

Indexed as

Dental Pulp DiseasesAdolescentAdultAgedCarcinoma, MucoepidermoidCarcinoma, Squamous CellChronic DiseaseDiagnosis, DifferentialFemaleHistiocytosis, Langerhans-CellHumansMaleMiddle AgedRetrospective StudiesSarcoma, EwingYoung Adultdiagnostic errorshead and neck neoplasmsneoplasmsnon‐endodontic lesionperiapical diseases

Identifiers

PMID40444645
PMCPMC12351104

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.