Evidence map›Paper›PMID 40444629›Full record

ArticleCurrent drug targets2025

RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19.

Sabrina Fulkerson, Grace Hohman, Tyler Stark, Selman Aydogdu, Mohamed Eldeeb

Abstract read
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In one paragraph

Article in Current drug targets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sabrina FulkersonDepartment of Chemistry, Illinois State University, Normal, IL, USA.
Grace HohmanDepartment of Chemistry, Illinois State University, Normal, IL, USA.
Tyler StarkDepartment of Chemistry, Illinois State University, Normal, IL, USA.
Selman AydogduDepartment of Chemistry, Illinois State University, Normal, IL, USA.
Mohamed EldeebDepartment of Chemistry, Illinois State University, Normal, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19), which led to a global pandemic causing millions of deaths, is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- -2). While previous research on COVID-19 has primarily utilized nasal swabs and blood samples, these do not provide comprehensive insights into all the organ systems affected by the infection. A recent study by Topper et al. addressed this gap by analyzing both nasal samples and autopsy tissues from SARS-CoV-2-infected individuals. Their findings highlight a significant role of mitochondrial damage pathways and RAAS overactivation in contributing to the severity of SARSCoV- 2 infections. Importantly, targeting mitochondrial dysfunction and RAAS overactivation pathways may offer promising and specific druggable targets for treating COVID-19 patients.

Indexed as

COVID-19MitochondriaRenin-Angiotensin SystemCOVID-19 Drug TreatmentHumansSARS-CoV-2Signal TransductionAldosteroneCOVID-19mitochondrial damagemitochondrial dysfunction.RAAS overactivationSARS-CoV-2

Identifiers

PMID40444629

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.