Evidence map›Paper›PMID 40444538›Full record

ArticleBrain and behavior2025

Incidence and Risk Factors of Post-Lumbar Puncture Headache in Patients With Cognitive Impairment.

Xinhui Wang, Yuchen Qiao, Yuchen Liang, Jinming Han, Hongyan Duan, Yi Tang, Qi Qin

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Xinhui WangDepartment of Geriatrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0009-8502-1145
Yuchen QiaoInnovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Yuchen LiangCapital Medical University, Beijing, China.
Jinming HanDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.ORCID https://orcid.org/0000-0002-6084-3275
Hongyan DuanDepartment of Geriatrics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
Yi TangInnovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China.
Qi QinInnovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China.

Funding

Beijing Nova ProgramCapital's Funds for Health Improvement and ResearchNational Natural Science Foundation of ChinaThe Henan Provincial Medical Science and Technology Youth Research Plan jointly supported by the Province and the MinistryThe Henan Provincial Science and Technology Research Plan
6 · The paper itself

Abstract

backgroundCognitive impairment is prevalent among the elderly population. Cerebrospinal fluid (CSF) biomarker tests are employed to facilitate timely and differential diagnosis of cognitive dysfunction.

objectiveTo investigate incidence and risk factors of post-lumbar puncture headache (PLPH) in Chinese geriatric patients with cognitive impairment.

methodsA total of 254 consecutive patients with cognitive impairment were recruited between March and September 2023 and categorized into two groups: mild cognitive impairment (MCI) and dementia. Different scales, such as the short-form of the McGill pain questionnaire (SF-MPQ), facial visual analogue scale (F-VAS), revised Wong-Baker Assessment of Facial Expression Pain (FPS-R), and Chinese version of Pain Assessment Scale for Advanced Dementia (C-PAINAD), were used to evaluate the incidence of headache after lumbar puncture. Univariate and multivariate factor analyses were conducted to identify potential risk factors, with the most influential predictors included in regression models.

resultsAmong patients with cognitive disorders, the incidence of PLPH was 24.8%. The incidence and duration of headache did not differ significantly between the MCI and dementia groups. The average time of post-lumbar puncture headache (PLPH) was 22.9 h. There was no significant difference in headache scale scores between MCI patients. The incidence of PLPH in women with cognitive impairment was higher than that in men. The incidence of PLPH in cognitive impairment patients with a history of headache was significantly higher than that in cognitive impairment patients without a history of headache. However, no significant differences were observed in years of education, number of lumbar punctures, length of bed rest, and oral rehydration volume.

conclusionPLPH is more commonly observed in women, individuals with a history of headache, younger age, or lower body mass index (BMI). C-PAINAD and SF-MPQ are the preferred assessment tools for evaluating PLPH in patients with cognitive impairment.

Indexed as

Cognitive DysfunctionPost-Dural Puncture HeadacheSpinal PunctureAgedAged, 80 and overChinaDementiaFemaleHumansIncidenceMaleMiddle AgedPain MeasurementRisk Factorsassessment toolscognitive impairmentlumbar puncturepost‐lumbar puncture headache (PLPH)

Identifiers

PMID40444538
PMCPMC12123446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.