ArticleClinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery2025
Adverse Effects of Steroid Therapy in Sudden Sensorineural Hearing Loss: A Scoping Review.
Article in Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07652528 (Steroid-induced Hyperglycemia Management With Insulin Patch Pump in Sudden Sensorineural Hearing Loss), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Steroid-induced Hyperglycemia Management With Insulin Patch Pump in Sudden Sensorineural Hearing Loss: a CGM-guided Exploratory Randomized Controlled Trial (SHIP Trial)
Who cites it
2 citing papers in PubMed.
- Migraine Features in Patients With Sudden Sensorineural Hearing Loss.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Adverse Effects of Steroid Therapy in Sudden Sensorineural Hearing Loss: A Scoping Review.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSudden sensorineural hearing loss (SSNHL) is an otologic emergency and is treated with steroid therapy. Despite adverse events (AEs) associated with long-term steroid use being well evidenced, there is sparsity of literature regarding the AEs of short-course prescriptions in the SSNHL cohort, which limits the quality of patient counselling and informed consent.
methodA literature search was performed on the Medline and Embase databases for studies assessing AEs in adults with SSNHL managed with oral (OST), intratympanic (ITS) and intravenous steroid therapy (IVS). Two authors screened titles, abstracts and full-text articles, with conflicts resolved by a third reviewer. Forty-three papers were included.
resultsIn systemic steroid therapies, hyperglycaemia and hypertension are reported in up to 29.8% and 37.9% of patients respectively. Patients with medication-dependent diabetes and hypertension are at higher risk. Gastric and mood disturbances affected up to 27.9% and 44.6% of patients respectively. ITS carried risks of otalgia (up to 54.3%), dizziness (up to 27.1%), perforations (up to 11.5%) and otitis media (up to 4.7%).
conclusionComprehensive counselling is key in obtaining informed consent, especially in cohorts with diabetes mellitus (DM) and hypertension where monitoring of glucose and blood pressure is recommended. Gastroprotection should be considered. Future focus is required to study short-term steroid AEs and raise awareness among prescribing clinicians and patients.
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