ArticleAngewandte Chemie (International ed. in English)2025
Mechanoactivated Celite as a Catalyst for C‒H Bond Perfluoroalkylation and Other Radical Reactions.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Trifluoromethylthio and Trifluoromethyl Functionalization of Endomorphin-1 Enhances its Hydrophobicity and Plasma Stability while Preserving its Affinity for the μ-Opioid Receptor.The Journal of organic chemistry · 2026Article
- Ball-Milling Assisted Iron-Catalyzed Difluoromethylation Toward the Synthesis of Valuable Oxindoles.ChemSusChem · 2025Article
- Mechanoactivated Celite as a Catalyst for C‒H Bond Perfluoroalkylation and Other Radical Reactions.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Herein, we report that Celite (diatomaceous earth) commonly viewed as an innocent filter aid or support material, or Earth-abundant, non-toxic metal oxides are efficient mechanoactivated catalysts for arene and heteroarene C─H bond radical trifluoromethylation and pentafluoroethylation, with the activity comparable with previously reported mechanochemical methods utilizing piezoelectric materials. Celite was also applied for mechanochemical dibromination of a double bond with N-bromosuccinimide, eliminating the need to use of lithium titanate as a piezoelectric mechanoredox catalyst. Mechanoactivation via ball milling in the presence of minimal amount of solvent was crucial to observe the reactivity, while sonication or using a pre-ground suspension in a bulk solvent were not efficient. The EDX studies and comparison with individual metal oxides suggest a possible role of trace metal oxides in mechanoinduced reactivity. Celite could be recycled and reused several times without significant loss of activity. This approach offers environmentally benign, biocompatible and inexpensive nature-inspired materials as efficient mechanocatalyts and conceptually broadens the scope of mechanoactivated solids to the materials previously deemed inert.
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Registered trials
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