ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Recent Advances in Application of Circularly Polarized Luminescence Probes toward Bioimaging Technology.Chemical & biomedical imaging · 2026Review
- Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
The differentiation and stemness maintenance of stem cells are the core topics in cell biology and regenerative medicine, involving cell fate determination, developmental regulation and tissue regeneration. Chirality is an essential factor influencing multiple biological processes, including protein interactions, stem cell development and disease pathogenesis. However, its roles in regulating stem cells fate, especially limbal epithelial stem cells (LESCs), remain elusive. Herein, it is first discovered that right-handed chiral hydrogel (DH) enhanced LESCs proliferation, migration, and differentiation into corneal epithelial cells, while left-handed chiral hydrogel (LH) can partially preserve LESCs stemness. Further in vivo experiments demonstrated that 3D DH effectively accelerated corneal wound healing process, inhibited both inflammation and vascularization in a partial limbal stem cell deficiency model. Mechanistically, DH activates Notch signaling by increasing its stereo-affinity to Notch1, facilitating Notch intracellular domain release and HES1 transcription, thereby directing LESCs fate. Collectively, this work highlights the novel role of chirality in LESCs fate determination and confirms DH as a drug-free, effective approach for corneal epithelial regeneration, offering a new direction for regenerative medicine and tissue engineering.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.