ArticleClinical transplantation2025
Postkidney Transplant Delayed Graft Function Outcomes Are Not Worsened by Deceased Donor Type.
Article in Clinical transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Survival and Outcomes of Lung-Kidney and Lung-Liver Transplants Using a Large National Cohort.Clinical transplantation · 2026Article
- Serum Creatinine Level at One Month Post-Transplant Predicts 3-Year and 5-Year Graft Survival and Renal Function: A Large Single-Center Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- The Detrimental Outcomes Associated With Kidney Delayed Graft Function Persist Beyond the Short Term.Transplantation direct · 2026Article
- Changes by Era in Risk Factors and Outcomes Among Deceased Donor Kidney Transplant Recipients With Delayed Graft Function.Clinical transplantation · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
introductionKidney-delayed graft function (DGF) is more common in donation after circulatory death (DCD) donors in comparison to donatation after brain death (DBD). We analyzed deceased kidney transplant recipients (DDKTR) at our center between 2005 and 2019, stratified by donor type (DBD vs. DCD).
methodsWe assessed risk factors for DGF, acute rejection (AR), graft failure (GF), along with the death with functioning graft (DWFG), and the interaction between types of donors for those complications.
resultsAmong 2543 DDKTRs, 804 (32%) were from DCD donors. Older donor age, higher recipient body mass index, and receipt of a depleting induction agent were associated with increased risk for DGF in both DBD and DCD. In contrast, preemptive transplant and female recipient gender were associated with reduced risk. Additional risk factors in DBD, but not in DCD recipients, included higher donor terminal serum creatinine, higher kidney donor profile index, right donor kidney, and prolonged cold ischemia time. Female donors were associated with a reduced risk of DGF only among DCD donors. DGF was associated with higher AR and GF, with no significant differences across donor types, DBD vs. DCD (AR: adjusted hazard ratio [aHR] 2.22 vs. 2.37, p-interaction = 0.65; GF: 3.04 vs. 2.56; p-interaction = 0.47). DGF was associated with a higher risk for DWFG among DBD (aHR: 3.43, 95% CI: 1.96-6.00, p < 0.001) but not with DCD (aHR: 1.90, 95% CI: 0.78-4.61, p = 0.16), with p-interaction of 0.15
conclusionDespite higher DGF rates in DCD, early adverse outcomes after DGF were similar between deceased donor types and should not deter the utilization of DCD kidneys.
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