ReviewEndocrinology2025
The Role of the Salt-inducible Kinases in the Endocrine Glands.
Review in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The salt-inducible kinases (SIKs), a family of serine/threonine kinases, are emerging endocrine regulators. The 3 isoforms, SIK1, SIK2, and SIK3, compose a subfamily of the 5' adenosine monophosphate-activated protein kinase-related kinases. The SIKs have multiple conserved protein kinase A phosphorylation sites by which they are regulated. Further, a family of well-characterized SIK targets is the cAMP response element binding protein regulated transcription coactivators, which promote cAMP response element-binding protein transcription. As such, the SIKs participate in several cAMP-dependent pathways, including classical GPCR cascades characteristic of endocrine signaling. This review discusses the currently known roles of the SIKs in the endocrine system. Specifically, the research on SIKs in this field up to this point has focused on the adrenal glands, ovary, pancreas, pineal gland, immune function of the thymus, parathyroid hormone signaling in the bone, and hypothalamic regulation of the circadian rhythm and endocrine axes. Furthermore, this review highlights the remaining questions in these areas and the glands in which little to no SIK research has been published: the testis, pituitary, thyroid gland, and parathyroid glands.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.