ArticleCirculation research2025
cDC1s Promote Atherosclerosis via Local Immunity and Are Targetable for Therapy.
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Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Dendritic Cells in the Immunoregulation of Myocardial Infarction: Mechanisms and Therapeutic Strategies.Cardiovascular drugs and therapy · 2026Review
- Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Inflammation and Immune Mechanisms in Atherosclerosis.Reviews in cardiovascular medicine · 2026Review
- The DC1 conundrum: Do type I dendritic cells make or break allograft tolerance?American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Review
- Pro-Inflammatory Activation Promotes Atherogenic Endothelial Phenotype in Male and Female Human Umbilical Endothelial Vein Cells (HUVECs).International journal of molecular sciences · 2026Article
- Transplantation immunology: paradigm shift from systemic suppression to microenvironment remodeling and precision modulation.Frontiers in cell and developmental biology · 2026Review
- Dendritic cells in cancer immunotherapy: functional barriers, reprogramming strategies and translational challenges.Frontiers in immunology · 2026Review
- Integrative genetic and expression profiling prioritizesFrontiers in immunology · 2026Article
- Integrated single-cell and bulk transcriptomic analyses reveal cDC1-centered ubiquitination dysregulation and identify UBE2F as a critical regulator in sepsis.Frontiers in immunology · 2026Article
- Dendritic Cells: Origin, Classification, Development, Biological Functions, and Therapeutic Potential.MedComm · 2025Review
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Authors and funding
24 authors.
Miguel GalánCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0002-6695-1509
Laura Fernández-MéndezCentro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastian, Spain (L.F.-M., S.C.-R., J.R.-C.).ORCID 0000-0002-8783-2330
Vanessa NúñezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).
Marcos Femenía-MuiñaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0009-0000-9742-3242
Pau Figuera-BelmonteCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0009-0003-9367-0643
Elena Moya-RuizCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0003-4157-5858
Sarai Martínez-CanoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).
Elena Hernández-GarcíaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0002-9018-5701
Manuel Rodrigo-TapiasCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).
Ana Rodríguez-RonchelCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0003-1589-5831
Carlos Relaño-RupérezCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0002-1407-9245
Stefanie K WculekInnate Immune Biology Laboratory, Institute for Research in Biomedicine (Institute for Research in Biomedicine [IRB] Barcelona), The Barcelona Institute of Science and Technology (BIST), Spain (S.K.W.).ORCID 0000-0001-5565-8561
Alberto BenguriaCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0002-5536-566X
Ana DopazoCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain (A.D.).ORCID 0000-0002-4910-1684
Sandrine HenriAix Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Consiglio Nazionale delle Ricerche (CNR), Centre d'Immunologie de Marseille-Luminy, France (S.H., B.M.).ORCID 0000-0002-8980-9193
Suin JoDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (S.J., T.-T.L., K.M.M.).ORCID 0000-0002-7575-9017
Tian-Tian LiuDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (S.J., T.-T.L., K.M.M.).ORCID 0000-0001-9377-9938
Bernard MalissenAix Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), Consiglio Nazionale delle Ricerche (CNR), Centre d'Immunologie de Marseille-Luminy, France (S.H., B.M.).ORCID 0000-0003-1340-9342
Kenneth M MurphyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO (S.J., T.-T.L., K.M.M.).ORCID 0000-0002-3505-9630
Almudena R RamiroCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0002-7539-3844
Susana Carregal-RomeroCentro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastian, Spain (L.F.-M., S.C.-R., J.R.-C.).ORCID 0000-0003-1444-6268
Jesús Ruiz-CabelloCentro de Investigación Cooperativa en Biomateriales (CIC biomaGUNE), Basque Research and Technology Alliance (BRTA), San Sebastian, Spain (L.F.-M., S.C.-R., J.R.-C.).ORCID 0000-0001-8681-5056
Iñaki Robles-VeraCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0001-6002-9241
David SanchoCentro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, Spain (M.G., V.N., M.F.-M., P.F.-B., E.M.-R., S.M.-C., E.H.-G., M.R.-T., A.R.-R., C.R.-R., A.B., A.R.R., I.R.-V., D.S.).ORCID 0000-0003-2890-3984
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAtherosclerosis is characterized by immune cell accumulation in the arterial wall and adaptive CD4
methodsWe tested atherosclerosis in
resultsExpansion of DCs in
conclusionsUsing state-of-the-art strategies, our results establish that cDC1s have a proatherogenic role in atherosclerosis by boosting CD4
Indexed as
AtherosclerosisDendritic CellsAnimalsDisease Models, AnimalMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNanoparticlesReceptors, LDLflt3 ligand proteinMembrane ProteinsReceptors, LDLatherosclerosisdendritic cellsimmunotherapymicenanoparticles
Identifiers
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.