Evidence map›Paper›PMID 40444335›Full record

Observational studyTherapeutic advances in respiratory disease

Intrapleural tissue plasminogen activator and deoxyribonuclease in complex pleural effusion and empyema, clinical outcomes, and predictors.

Yub Raj Sedhai, Priyanka Bhat, Roshan Acharya, Nada Qaiser Qureshi, Fawaz Mohammed, Irfan Waheed, Tahir Muhammad Abdullah Khan, Muhammad Altaf Ahmed, Nisarfathima Kazimuddin, Akinchan Kafle and 2 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yub Raj SedhaiDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, 250 Park St. Bowling Green, KY 42101, USA.ORCID 0000-0002-1755-5489
Priyanka BhatDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Roshan AcharyaDivision of Pulmonary Disease and Critical Care Medicine, Carillion Clinic, Roanoke, VA, USA.
Nada Qaiser QureshiDivision of Internal Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Fawaz MohammedDivision of Internal Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Irfan WaheedDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Tahir Muhammad Abdullah KhanDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Muhammad Altaf AhmedDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Nisarfathima KazimuddinDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Akinchan KafleDivision of Anatomy, Tribhuvan University, Institute of Medicine, Kathmandu, Nepal.
Rodney T SteffDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.
Karan SinghDivision of Pulmonary Disease, and Critical Care Medicine, University of Kentucky College of Medicine, Bowling Green, KY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundComplex pleural effusion and empyema (CPPE) is treated with intrapleural fibrinolytic therapy (IPFT) using tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) We present our single-center retrospective observational data using a simplified regimen of coadministering six divided doses of tPA and DNase over the course of 3 days.

objectiveTo study the safety, utility, and clinical outcomes of IPFT.

designThis is a single-center retrospective study of patients who received co-administration tPA/DNase for CPPE over a period of 5 years. The primary outcome was successful treatment without the need for surgery. Secondary outcomes were bleeding risk, post-procedural pain, treatment complications, and all-cause mortality at 30 days and 6 months. We have tested the clinical role RAPID score (Renal function measured as urea, Age, fluid Purulence, Infection source, Dietary status measured as albumin) to predict treatment success, and all-cause mortality at 6 months.

resultsA total of (

conclusionResults of our single-center study suggest that IPFT can be safely adopted by small and mid-sized clinical centers, as the risk of bleeding is low. The results of coadministering tPA and DNase are safe, and it reduces the need for surgical intervention in nearly one-third of patients.

Indexed as

DeoxyribonucleasesEmpyema, PleuralFibrinolytic AgentsPleural EffusionThrombolytic TherapyTissue Plasminogen ActivatorAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeDeoxyribonucleasesFibrinolytic AgentsTissue Plasminogen Activatorcomplex pleural effusionempyemaparapneumonic effusionpleural effusion

Identifiers

PMID40444335
PMCPMC12126679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.