Evidence map›Paper›PMID 40444282›Full record

ArticlePeerJ2025

BNC1 inhibits the development and progression of gastric cancer by regulating the CCL20/JAK-STAT axis.

Lixin Liu, Li Xiong, Hong Peng, Qin Deng, Kang Liu, Shusen Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lixin LiuThe Second Department of Gastrointestinal Surgery, The Affiliated Hospital of the North Sichuan Medical College, Nanchong, Sichuan, China.
Li XiongDepartment of Clinical Laboratory, People's Hospital of Leshan, Leshan, Sichuan, China.
Hong PengDepartment of Anorectal Surgery, Nanchong Central Hospital, The Second clinical Medical College, North Sichuan Medical College, Nanchong, Sichuan, China.
Qin DengSchool of Clinical Medicine, Guizhou Medical University, Guiyang, Guizhou, China.
Kang LiuInstitute of Tissue Engineering and Stem Cell, Beijing Anzhen Nanchong Hospital of Capital Medical University, Nanchong Central Hospital, The Second Clinical Medical College of North Sichuan Medical College, Nanchong, Sichuan, China.
Shusen XiaThe Second Department of Gastrointestinal Surgery, The Affiliated Hospital of the North Sichuan Medical College, Nanchong, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of basonuclin 1 (BNC1), a zinc finger protein-specific transcription factor, in gastric cancer remains unclear. In this study, BNC1 was downregulated in gastric cancer and functioned as a tumor suppressor. Through integrative analyses of transcriptome sequencing and functional assays, C-C motif chemokine ligand 20 (CCL20) was identified as a direct downstream target of BNC1. Overexpression of BNC1 inhibited the proliferation, migration, and invasion of gastric cancer cells both

Indexed as

Chemokine CCL20DNA-Binding ProteinsJanus KinasesSTAT Transcription FactorsStomach NeoplasmsTranscription FactorsTumor Suppressor ProteinsAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDisease ProgressionGene Expression Regulation, NeoplasticHumansMiceCCL20 protein, humanChemokine CCL20DNA-Binding ProteinsJanus KinasesSTAT Transcription FactorsTranscription FactorsTumor Suppressor ProteinsBNC1CCL20Gastric CancerJAK2/STAT3

Identifiers

PMID40444282
PMCPMC12121617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.