ArticleFrontiers in endocrinology2025
Impaired sensitivity to thyroid hormones is positively associated to metabolic syndrome severity in euthyroid Chinese adults as revealed by a cross-sectional study.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Association between central thyroid hormone dysregulation and chronic kidney disease in type 2 diabetes: a cross-sectional study.Renal failure · 2026Article
- Endocrine-Metabolic Crosstalk Between Diabetes Mellitus and Hypothyroidism: From Network Mechanisms to Translational Stratification.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Article
- Thyroid Hormone Indices and Histopathological Severity of Diabetic Nephropathy in Euthyroid Patients with Type 2 Diabetes: A Biopsy-Based Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
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Abstract
Objective: Thyroid hormones (THs) play a pivotal role in regulating metabolism, and their sensitivity may influence the risk of metabolic syndrome (MetS). This study aimed to investigate the association of impaired sensitivity to THs with MetS and MetS severity score (MetSSS) in Chinese euthyroid adults. Methods: A cross-sectional analysis was conducted involving 17,272 health check-up participants. THs sensitivity indices, including Thyroid Feedback Quantile-Based Index (TFQI), Parametric Thyroid Feedback Quantile-Based Index (PTFQI), TSH Index (TSHI), Thyrotropin Thyroxine Resistance Index (TT4RI), and free triiodothyronine/free thyroxine (FT3/FT4) ratio were assessed. Multivariable regression and restricted spline cubic analyses were conducted to explore the association between THs sensitivity indices and MetS and MetSSS. Subgroup analysis was also performed to examine this association stratified by sex and age. Results: Multivariable logistic regression analysis indicated that MetS risk was positively associated with all impaired THs sensitivity indices (per SD increase) (TFQI: OR=1.20, 95%CI: 1.15-1.25); PTFQI: OR=1.28, 95%CI: 1.23-1.33; TSHI: OR=1.35, 95%CI: 1.29-1.42; TT4RI: OR=1.57, 95%CI: 1.47-1.67; FT3/FT4: OR=1.17, 95%CI: 1.12-1.23)(all P-value<0.001). After adjusting for confounders, compared with the lowest group of MetSSS, individuals in the highest group of MetSSS were positively associated with all impaired THs sensitivity indices (per SD increase) (TFQI: OR=1.16, 95%CI: 1.07-1.21 PTFQI: OR=1.12, 95%CI: 1.06-1.17; TSHI: OR=1.13, 95%CI: 1.06-1.19; TT4RI: OR=1.25, 95%CI: 1.15-1.35; FT3/FT4: OR=1.82, 95%CI: 1.72-1.93). Nonlinear associations were found between THs sensitivity indicators and MetS (P for non-linear<0.001). Subgroup analysis indicated that all thyroid hormones sensitivity indices were positively associated with MetS by gender (male/female) and age (<60 years/≥60 years). Conclusion: Impaired sensitivity to THs is associated with an increased risk of MetS and MetSSS in Chinese euthyroid adults. Future research should consider thyroid hormones sensitivity indices in the assessment of MetS risk.
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