ArticleNeuro-oncology advances
Distinct gut microbiota composition in pediatric patients with central nervous system (CNS) tumors: A comparative study.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Gut Microbiota and Central Nervous System Tumors: A Comprehensive Systematic Review and Meta-Analysis of Microbiome-CNS Interactions.International journal of molecular sciences · 2025Pooled it
- Gut microbiota and glioblastoma: composition, mechanisms, and therapeutic interventions.Infectious agents and cancer · 2026Review
- QIIME2 enhances multi-amplicon sequencing data analysis: a standardized and validated open-source pipeline for comprehensive 16S rRNA gene profiling.Microbiology spectrum · 2025Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Central nervous system (CNS) tumors are the leading cause of cancer-related deaths in children aged 0-14 years. Despite significant efforts, targeted therapies based on identified pathways have not improved survival rates. Research has shown that the gut microbiota (GM) can influence brain tumor cell proliferation, suggesting that the microbiota-gut-brain axis plays a role in CNS cancer. Our study aims to assess whether the GM composition in pediatric CNS tumors exhibits specific characteristics. Methods: The study included 18 pediatric patients, 9 diagnosed with CNS tumors (CNS tumors group) and 9 with other tumor types (extra-CNS tumors group). Microbial DNA was extracted from stool samples, and 16S DNA libraries were generated and sequenced. GM composition was analyzed using amplicon sequence variant (ASV) tables. Results: Alpha-diversity analysis, represented by the number of observed features, was lower in the CNS tumors group ( Conclusions: Pediatric patients with CNS tumors have a distinct GM composition. The reduction of specific beneficial microbial taxa may contribute to tumor growth through the microbiota-gut-brain axis.
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