Evidence map›Paper›PMID 40444076›Full record

SynthesisFrontiers in oncology2025

The evolution of FLASH radiotherapy: a bibliometric analysis.

Shuokai Jia, Weige Wei, Yiwen He, Haichuan Yan, Shiru Zou, Yanmei Hao, Qing Xiao, Guangjun Li

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shuokai Jia *Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Weige Wei *Department of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yiwen HeDepartment of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Haichuan YanDepartment of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Shiru ZouDepartment of Radiotherapy Physics & Technology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Yanmei HaoDepartment of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Qing XiaoDepartment of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Guangjun LiDepartment of Radiation Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: FLASH radiotherapy (FLASH-RT) represents a groundbreaking technique, characterized by its ultra-high dose rate and its remarkable ability to spare normal tissues from damage. Numerous studies on FLASH-RT have been conducted worldwide. However, to date, no comprehensive bibliometric analysis has been performed in this field. This study aims to provide an overview of the advancements in FLASH-RT and identify potential future research directions through bibliometric analysis. Method and materials: The research team performed a literature search in the Web of Science Core Collection (WOSCC), covering the period from 1967 to 2024, and identified 461 publications relevant to the field of interest. Visualization tools, including VOSviewer, CiteSpace, and Bibliometrix, were employed to analyze countries, institutions, authors, journals, references, and keywords, thereby uncovering research frontiers and hotspots within the field. Results: In recent years, a considerable number of publications on FLASH-RT have emerged. The United States has the highest number of publications (n=208). The institution with the highest publication count is "Lausanne University Hospital" (n=39). The author with the most citations is "Vozenin, M" (n=31), while the author with the most co-citations is "Montay-Gruel, P" (n=812). Medical Physics is the journal with the highest number of both publications and co-citations, whereas Radiotherapy and Oncology has the highest number of citations. The paper titled "Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice" has the highest number of both citations and co-citations. The most frequently co-occurring keywords is "FLASH radiotherapy" (n=379). Conclusions: Our bibliometric analysis of FLASH-RT explores key dimensions of the field, including publication trends, international collaborations, influential journals and authors, and keyword evolution. It assesses FLASH-RT's historical development, current global status, and recent progress in biological mechanisms, equipment, and clinical translation, aiming to offer researchers a comprehensive overview.

Indexed as

bibliometric analysisbiological mechanismsdeviceFLASH radiotherapy (FLASH-RT)preclinical and clinical trialsultra-high dose rate (UHDR)

Identifiers

PMID40444076
PMCPMC12119588

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.