Evidence map›Paper›PMID 40444025›Full record

ArticlePain reports2025

The role of puberty in experimental pain sensitivity in healthy adolescent girls.

Hadas Nahman-Averbuch, Gourav Banerjee, Joel Brown, Alana McMichael, Arbi Ben Abdallah, Sarah Buday, Thomas Baranski, Simon Haroutounian, Deanna Barch, Sarah Garwood and 1 more

Abstract read
In one paragraph

Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hadas Nahman-AverbuchDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Gourav BanerjeeDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Joel BrownDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Alana McMichaelDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Arbi Ben AbdallahDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Sarah BudayDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Thomas BaranskiDivision of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St. Louis, MO, USA.
Simon HaroutounianDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.
Deanna BarchDepartments of Psychological & Brain Sciences, Psychiatry, and Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Sarah GarwoodTransgender Center at St. Louis Children's Hospital, Washington University School of Medicine, St. Louis, MO, USA.
Jacob AuBuchonDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, MO, USA.

Funding

Migraine Onset in Adolescent GirlsR01NS129742 · NINDS · WASHINGTON UNIVERSITY · PI Hadas Nahman-Averbuch · 2023 to 2026
$2.4M
NINDS NIH HHS R01 NS129742
6 · The paper itself

Abstract

Introduction: Puberty is a critical developmental period during which changes in pain sensitivity are observed. Previous studies found that older and more mature adolescents have lower experimental pain sensitivity. However, it is unclear whether the differences in pain sensitivity are due to age or the pubertal maturation effect. Objectives: This observational study examined the relationships between the pubertal maturation stage, age, and experimental pain sensitivity in healthy girls. Methods: Healthy adolescent girls (n = 52, mean age 12.0 ± 1.4 years) completed the Pubertal Developmental Scale (PDS) to assess their pubertal stage. In addition, they completed a comprehensive quantitative sensory testing session, including pain thresholds, pain ratings to noxious stimuli, and pain modulation tests. Separate regression models were performed to assess the effect of pubertal maturation and age on experimental pain sensitivity as well as differences in experimental pain sensitivity between girls in different subjective self-perceived pubertal timing relative to peers. Results: No relationships were found between the PDS score and experimental pain sensitivity; however, age was significantly related to cold pain tolerance ( Conclusion: Puberty and age may have no effect on experimental pain sensitivity in healthy girls.

Indexed as

AdolescentsAgePubertyQuantitative sensory testing

Identifiers

PMID40444025
PMCPMC12119044

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.