ArticleBrain communications2025
Sensitivity of diffusion tensor imaging to regional mixed cerebrovascular pathology.
Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Diffusion tensor imaging is a candidate biomarker in cerebrovascular disease. Yet, little is known about the sensitivity of diffusion tensor imaging to mixed forms of cerebrovascular pathology: stroke and white matter hyperintensities. We evaluated the sensitivity of diffusion tensor imaging to regional lesion load, considering both stroke and white matter hyperintensity lesions. 65 older adults and 39 individuals with chronic stroke underwent diffusion tensor imaging and comprehensive cerebrovascular lesion segmentation. We tested relationships between fractional anisotropy or mean diffusivity and cerebrovascular lesions with linear mixed effects regression. In older adults, tract microstructure related to white matter hyperintensity lesion load (fractional anisotropy:
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