Evidence map›Paper›PMID 40443846›Full record

ArticleOxford medical case reports2025

Increased caries risk in a Xerostomic patient with Darier disease: a case report of incipient and advanced carious lesions.

Kostis Giannakopoulos, Persefoni Lambrou, Eleftherios G Kaklamanos, Maria Nefeli Christodoulou

Abstract readCase Reports
In one paragraph

Article in Oxford medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Darier disease-A review highlighting new insights from the Darier Disease International Task Force.Journal of the European Academy of Dermatology and Venereology : JEADV · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kostis GiannakopoulosSchool of Dentistry, European University Cyprus, 6 Diogenes str, 2404 Engomi, Nicosia, Cyprus.ORCID https://orcid.org/0000-0001-7008-7306
Persefoni LambrouScientific Collaborator, School of Dentistry, European University Cyprus, 6 Diogenes str, 2404 Engomi, Nicosia, Cyprus.ORCID https://orcid.org/0000-0002-1500-1896
Eleftherios G KaklamanosSchool of Dentistry, European University Cyprus, 6 Diogenes str, 2404 Engomi, Nicosia, Cyprus.ORCID https://orcid.org/0000-0002-0513-5110
Maria Nefeli ChristodoulouWest Suffolk Hospital: Bury St Edmunds, GB.ORCID https://orcid.org/0009-0001-1553-1870

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Darier disease is a rare autosomal dominant inherited skin disorder, caused by mutations in the ATP2A2 gene. Oral manifestations can include mucosal lesions, salivary gland involvement, and xerostomia, that can significantly increase the risk of dental caries. A 58-year-old female with a confirmed diagnosis of Darier disease presented with oral manifestations, including recurrent sublingual blisters, xerostomia, and carious lesions. The intraoral examination revealed white spot carious lesions and cavitated caries, particularly in the cervical areas of several teeth. Dental treatment included fluoride mouthrinse, oral hygiene instructions, and restorative care for the cavitated teeth. The patient was also advised on preventive and symptomatic measures for xerostomia. Dentists should be aware of these potential issues and provide appropriate preventive, etiologic and symptomatic care. Regular follow-ups are essential to monitor the progression of dental lesions and manage oral health in patients with Dd.

Indexed as

carious lesionsDarier diseasedental carieswhite spotsxerostomia

Identifiers

PMID40443846
PMCPMC12118073

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.