ArticleRSC advances2025
Successive paired electrochemical late-stage modification of niclosamide a common anthelmintic drug. A green protocol for the synthesis of new drug-like molecules.
Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drugs based on salicylanilides such as niclosamide are of particular interest to medicinal chemistry researchers. They exhibit a wide range of biological activities, including anticancer and antiviral activities. Niclosamide is a common oral anthelmintic that has the potential to be an antiviral and anticancer drug. However, two characteristics of it, including poor oral bioavailability and high cytotoxicity, have limited its use. The synthesis of new niclosamide analogs is an attempt to overcome these limitations. The electrochemical behavior of niclosamide shows that the drug can be reduced and then oxidized at the cathode and anode, respectively. This property, along with the special capabilities of electrosynthesis methods, makes it possible to obtain unique niclosamide analogs. In this study, novel niclosamide analogs were synthesized
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Registered trials
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