Evidence map›Paper›PMID 40443665›Full record

ArticleFrontiers in immunology2025

Spesolimab in generalized pustular psoriasis complicated by acrodermatitis continua of Hallopeau: a case report and mechanistic insights.

Xin-Yi Hou, Hai-Lu Xiao, Jing-Yu Wang, Jin Zhang, Bo Ren, Chu-Chu Niu, Fei-Fei Liu, Bin Lu

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin-Yi HouDepartment of Dermatology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Hai-Lu Xiao *Department of Dermatology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Jing-Yu Wang *School of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
Jin Zhang *School of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
Bo Ren *School of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
Chu-Chu Niu *School of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
Fei-Fei Liu *Department of Pathology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Bin LuDepartment of Dermatology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 62-year-old Chinese woman presented to the hospital for help with generalized pustular psoriasis (GPP) and acrodermatitis continua of Hallopeau (ACH). While conventional treatments failed to achieve significant improvement, the patient received two doses of spesolimab, and the effect was remarkable. No adverse reactions were observed in the follow-up period.

Indexed as

AcrodermatitisAntibodies, Monoclonal, HumanizedPsoriasisFemaleHumansMiddle AgedTreatment OutcomeAntibodies, Monoclonal, Humanizedacrodermatitis continua of Hallopeaugeneralized pustular psoriasisIL-1IL-36 pathwayspesolimab

Identifiers

PMID40443665
PMCPMC12119614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.