Evidence map›Paper›PMID 40443627›Full record

ArticleCureus2025

Double Trouble: A Case Report of Hydralazine-Induced Vasculitis and Lupus.

Malika Ibrahim, Thanda Aung, Sravani Penumarty

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Malika IbrahimDepartment of Medicine, Division of Rheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Thanda AungDepartment of Medicine, Division of Rheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.
Sravani PenumartyDepartment of Medicine, Division of Rheumatology, University of California Los Angeles David Geffen School of Medicine, Los Angeles, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present a rare case of hydralazine-induced antineutrophil cytoplasmic antibody (ANCA) vasculitis and lupus, characterized by the simultaneous and severe involvement of multiple organ systems. Following outpatient hydralazine dose escalation, a 77-year-old woman developed hypoxic respiratory failure secondary to diffuse alveolar hemorrhage, acute kidney injury with crescentic glomerulonephritis, and pancytopenia. Serologic testing revealed positive antinuclear antibody (ANA), dsDNA, anti-histone antibody, and P-ANCA, supporting the diagnosis of drug-induced autoimmune syndrome. This case highlights the risk for severe multi-organ dysfunction in drug-induced lupus and vasculitis, emphasizing the need for vigilance in recognizing such complications.

Indexed as

anca-associated vasculitishydralazine-induced diffuse alveolar hemorrhagehydralazine-induced dual aav and dilhydralazine-induced lupus syndromehydralazine-induced lupus syndrome (hils)hydralazine toxicitysystemic lupus erythematosussystemic lupus erythromatosus

Identifiers

PMID40443627
PMCPMC12122051

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.