Evidence map›Paper›PMID 40443618›Full record

ArticleCureus2025

Hemophagocytic Lymphohistiocytosis in the Setting of Progressive Chronic Lymphocytic Leukemia With Five Concurrent Life-Threatening Infections.

Heenaben Patel, John Patresan, Victoria Krzywicki, Andres Ramirez Gamero, Gerald Colvin

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Heenaben PatelInternal Medicine, Roger Williams Medical Center, Providence, USA.
John PatresanHematology and Medical Oncology, Roger Williams Medical Center, Providence, USA.
Victoria KrzywickiHematology and Medical Oncology, Roger Williams Medical Center, Providence, USA.
Andres Ramirez GameroInternal Medicine, Roger Williams Medical Center, Providence, USA.
Gerald ColvinHematology and Medical Oncology, Roger Williams Medical Center, Providence, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Untreated hemophagocytic lymphohistiocytosis (HLH) can be fatal and requires a high degree of clinical suspicion in the setting of an underlying autoimmune disorder, infection, or malignancy. In the presence of multiple infections, it can be challenging to treat the disease, given organ failure and limited options. We present a case of HLH in a patient with chronic lymphocytic leukemia, who was found to have multiple bacterial and fungal infections simultaneously, due in part to construction work on his 200-year-old home.

Indexed as

chronic lymphocytic leukemia (cll)hemophagocytic lymphohistiocytosis (hlh)infectioninvasive aspergillosismalignancy

Identifiers

PMID40443618
PMCPMC12122104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.