Evidence map›Paper›PMID 40443556›Full record

ArticleChemical & biomedical imaging2025

A Near-Infrared Fluorescent Probe for Visualization of Acetylcholinesterase Flux in the Acute Epileptic Mice Brain.

Li Fan, Rui Wang, Qi Zan, Kunyi Zhao, Yuewei Zhang, Yunong Huang, Xue Yu, Yongming Yang, Wenjing Lu, Shaomin Shuang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li FanInstitute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.ORCID https://orcid.org/0009-0000-2721-0612
Rui WangInstitute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.
Qi ZanInstitute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.
Kunyi ZhaoInstitute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.
Yuewei ZhangSchool of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China.ORCID https://orcid.org/0000-0001-6696-0336
Yunong HuangSchool of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China.
Xue YuSchool of Chemistry and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China.
Yongming YangLaboratory Animal Center, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, People's Republic of China.
Wenjing LuInstitute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.ORCID https://orcid.org/0000-0003-4702-5777
Shaomin ShuangInstitute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.ORCID https://orcid.org/0000-0003-2880-5444
Xihua YangLaboratory Animal Center, Shanxi Province Cancer Hospital/Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan 030013, People's Republic of China.
Chuan DongInstitute of Environmental Science, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, People's Republic of China.ORCID https://orcid.org/0000-0002-1827-8794

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotransmitter imbalance is an important pathological basis for epilepsy seizures. Acetylcholinesterase (AChE) as a key hydrolase in the cholinergic system directly affects the metabolism of neurotransmitter. Unfortunately, owing to the lack of reliable in situ imaging tools in the brain, the association between AChE and epilepsy has not been fully elucidated yet. Here, we rationally designed a near-infrared (NIR) fluorescent probe (

Indexed as

Acetylcholinesterase (AChE)EpilepsyFluorescence imagingFluorescent probeNear-infrared (NIR)

Identifiers

PMID40443556
PMCPMC12117416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.