Evidence map›Paper›PMID 40443554›Full record

ArticleChemical & biomedical imaging2025

Tuning SBDs as Endoplasmic Reticulum Self-Targeting Fluorophores and Its Application for Zn

Mingfeng Li, Hao Yuan, Yuncong Chen, Shankun Yao, Zijian Guo, Weijiang He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical & biomedical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingfeng LiState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, Nanjing 210023, China.
Hao YuanState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, Nanjing 210023, China.
Yuncong ChenState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-8406-4866
Shankun YaoState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, Nanjing 210023, China.
Zijian GuoState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, Nanjing 210023, China.ORCID https://orcid.org/0000-0003-4986-9308
Weijiang HeState Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu, Nanjing 210023, China.ORCID https://orcid.org/0000-0002-3157-5769

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emerging endoplasmic recticulum (ER) crosstalk system demands a more reliable approach for ER-targeting fluorophores to explore ER-associated biochemical species and events. Providing the aromatic sulfonamides' affinity to ATP-sensitive potassium channel protein localized mainly on ER membrane, the sulfonamide fluorophore 4-amino-7-sulfamoylbenzoxadiazole (SBD) was modified to construct ER self-targeting fluorophores without any additional targeting group by alternating the N-substituent structure and numbers of its 4-amino and 7-sulfamoyl groups. The results revealed that a ClogP value over 3.0 endowed those SBDs the ER self-targetability effectively. This provides a strategy to devise an ER-targeting probe by simply modifying the 4-amino group of SBDs as a sensing moiety to make the probe CLogP over 3.0 despite the CLogP value of parent SBDs, and two ER-targeting Zn

Indexed as

Cell imagingEndoplasmic reticulumER stressProbe designZn2+

Identifiers

PMID40443554
PMCPMC12117392

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.