Evidence map›Paper›PMID 40443457›Full record

ArticleJCEM case reports2025

Ovarian Hyperthecosis Presenting With Postmenopausal Virilization and New-Onset Type 2 Diabetes.

Jeremy A Knott, Jack Morris

Abstract readCase Reports
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Approach to the patient: investigation of postmenopausal androgen excess.The Journal of clinical endocrinology and metabolism · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jeremy A KnottDepartment of Endocrinology, Wollongong Hospital, Wollongong, NSW 2500, Australia.ORCID https://orcid.org/0009-0009-9981-5384
Jack MorrisDepartment of Endocrinology, Shoalhaven District Memorial Hospital ISLHD, Nowra, NSW 2541, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Postmenopausal virilization accompanied by insulin resistance is rare and may present as a diagnostic challenge. Ovarian hyperthecosis is characterized by ovarian stromal cell proliferation, leading to androgen excess and associated insulin resistance. Here, we present a case of a 58-year-old postmenopausal woman with new onset virilization and associated type 2 diabetes due to ovarian hyperthecosis, who was successfully treated with bilateral oophorectomy, resulting in normalization of hyperandrogenism and improvement in glycemic control along with metformin and lifestyle advice. This case underscores the importance of recognizing ovarian hyperthecosis as a differential diagnosis when assessing new onset virilization and metabolic disturbance in postmenopausal women.

Indexed as

hirsutismhyperandrogenismmetabolic syndromeovarian hyperthecosispostmenopausal virilization

Identifiers

PMID40443457
PMCPMC12120133

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.