ArticleJournal of translational internal medicine2025
Benzo[b]fluoranthene is involved in idiopathic membranous nephropathy by inducing podocyte injury.
Article in Journal of translational internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A study on the association between polycyclic aromatic hydrocarbon (PAH) exposure and kidney function indicators in adolescents: an integrated research combining statistical mediation analysis and network toxicology.International urology and nephrology · 2026Article
- The Influence of the Main Components of Tobacco Smoke, E-Cigarettes, and Air Pollutants on the Development of Glomerulonephritis.Journal of clinical medicine · 2026Review
- Rapid and accurate preoperative diagnosis of urinary tract infections in urolithiasis patients: clinical validation of the HB&L system.BMC infectious diseases · 2026Article
- Immunotherapy of membranous nephropathy: strategic evolution from CD20 monoclonal antibodies to future vaccines.Frontiers in immunology · 2026Review
- Cellular senescence of renal tubular epithelial cells in diabetic kidney disease: emerging mechanisms and targeted interventions.Frontiers in cell and developmental biology · 2026Review
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Authors and funding
8 authors.
Funding
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Abstract
Background and Objectives: The incidence of idiopathic membranous nephropathy (IMN) has been increasing in recent years and is closely correlated with fine particulate matter particulate matter (PM) 2.5. Thus, the relationship between polycyclic aromatic hydrocarbons (PAHs), one of the main components of PM2.5, and IMN should be explored. Methods: Patients with IMN and healthy control (HC) individuals were screened, and the concentrations and clinical indicators of blood PAHs were detected in these two groups for statistical analysis. Immortalized mouse podocyte cells were treated with 6.25, 12.5, and 25 μg/mL Benzo[b]fluoranthene (BbF) for 72 h. The cell morphology was observed, and the expressions of nephrin and synaptopodin (Synpo) were detected. On days 0 and 2, 1.25 mg/kg BbF was intratracheally administered to the rats. The rats were sacrificed on day 0, day 3, day 7, and day 14. The glomerulus was observed under a microscope, and the nephrin expression was detected. Results: Compared with the HC group, the total concentration of PAHs in the IMN group was significantly increased ( Conclusion: This study showed that the total concentration of PAHs in the blood of patients with IMN significantly increased, and BbF is significantly correlated with the disease severity of IMN, suggesting that PAHs are correlated with IMN occurrence and development and may play a certain role in IMN.
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