Evidence map›Paper›PMID 40443355›Full record

ArticleDiabetes care2025

GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes Mellitus and Offspring BMI Growth: The EPOCH Study.

Kylie K Harrall, Deborah H Glueck, Leslie A Lange, Elizabeth M Litkowski, Lauren A Vanderlinden, Iain R Konigsberg, Melanie G Cree, Wei Perng, Dana Dabelea

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kylie K HarrallLifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0003-4467-2282
Deborah H GlueckDepartment of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Leslie A LangeDepartment of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO.
Elizabeth M LitkowskiDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO.
Lauren A VanderlindenDivision of Rheumatology, University of Colorado School of Medicine, Aurora, CO.
Iain R KonigsbergDepartment of Biomedical Informatics, University of Colorado School of Medicine, Aurora, CO.
Melanie G CreeDivision of Pediatric Endocrinology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO.
Wei PerngLifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, CO.
Dana DabeleaLifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, Aurora, CO.

Funding

Computational Bioscience Program Training GrantT15LM009451 · NLM · UNIVERSITY OF COLORADO DENVER · PI Katherina Kechris-Mays, Arjun Krishnan · 2007 to 2026
$11.7M
Exploring the Fetal Origins Hypothesis in Diverse YouthR01DK068001 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2015
$4.5M
Division of Diabetes, Endocrinology, and Metabolic Diseases R01DK068001NIDDK NIH HHS R01 DK068001NLM NIH HHS T15 LM009451
6 · The paper itself

Abstract

objectiveExposure to maternal gestational diabetes mellitus (GDM) is associated with childhood BMI. Among youth, we explored whether three different glucagon-like peptide 1 receptor gene (GLP-1R) polymorphisms modified the associations between 1) GDM and BMI trajectories and 2) GDM and markers of glucose-insulin homeostasis. RESEARCH DESIGN AND

methodsFor 464 participants from the Exploring Perinatal Outcomes Among Children (EPOCH) study, microarray genotyping was performed during childhood (∼10 years). BMI trajectories across childhood and adolescence were characterized using repeated measurements from research visits and medical record abstraction. Markers of glucose-insulin homeostasis were derived from one oral glucose tolerance test in adolescence (∼16 years). Linear models assessed effect modification by GLP-1R polymorphisms.

resultsAmong youth with at least one minor allele of rs10305420 (CT or TT) or rs1042044 (CA or AA), but not among major allele homozygotes, exposure to GDM was associated with higher average BMI. For rs6923761, participants who were exposed to GDM and were major allele homozygotes (i.e., genotype GG) had significantly higher average BMI than all other participants in the cohort. No polymorphisms modified the association between GDM and markers of glucose-insulin homeostasis during adolescence.

conclusionsGLP-1R polymorphisms modify the association between GDM and BMI growth among youth. Further studies are needed to replicate these findings, and to better understand the mechanisms by which GLP-1R polymorphisms lead to heterogeneity in offspring BMI growth.

Indexed as

Body Mass IndexDiabetes, GestationalGlucagon-Like Peptide-1 ReceptorAdolescentChildFemaleGenotypeHumansMalePolymorphism, GeneticPolymorphism, Single NucleotidePregnancyGLP1R protein, humanGlucagon-Like Peptide-1 Receptor

Identifiers

PMID40443355
PMCPMC12178627

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.