SynthesisBrain and behavior2025
Dementia in People With Multiple Sclerosis: A Systematic Review and Meta-Analysis.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Is there a link between multiple sclerosis and Alzheimer disease? A critical note.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Multiple sclerosis and the risk of dementia: a real-world, nationwide cohort study.Frontiers in neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMultiple sclerosis (MS), as an autoimmune demyelinating disorder, is associated with cognitive dysfunction. Dementia can result from severe cognitive dysfunction or other pathways in MS, but the exact mechanisms and prevalence are unknown.
objectiveThis review aimed to determine the pooled prevalence and risk of dementia in people with MS (PwMS).
designThis meta-analysis was performed in accordance with the guidelines established by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA).
methodsEmbase, PubMed, Web of Science, and Scopus were comprehensively searched up to August 29, 2024, to identify observational studies that examined the prevalence or hazard ratio (HR) of dementia among PwMS. This meta-analysis used a random-effects model to calculate the pooled prevalence and risk of dementia among PwMS, where the prevalence rate and HR were the main metrics for effect size.
resultsTen studies, including a total of 37,831 PwMS, estimated the prevalence of dementia in PwMS to be 5.31% (I
conclusionWhile dementia is not a common feature of MS, PwMS still have a significantly higher risk of developing it, compared to healthy indiviuals. However, the considerable variability across studies indicates that these estimates should be interpreted with caution, as inconsistencies in research approaches may have influenced the results. These findings warrant further validation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.