ArticleACS applied bio materials2025
Dual-Mode Electrochemical Biosensor Based on Gold Nanoparticles/Two-Dimensional MoWS
Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Rapid and sensitive electrochemical detection of paracetamol using EuZrOScientific reports · 2025Article
- Functional Nanomaterials for Advanced Bioelectrode Interfaces: Recent Advances in Disease Detection and Metabolic Monitoring.Sensors (Basel, Switzerland) · 2025Review
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Authors and funding
3 authors.
Funding
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Abstract
Diabetes, a widespread chronic disease, is characterized by dysregulated blood glucose levels, necessitating early diagnosis for effective management and complication prevention. To address the need for a more comprehensive diagnostic approach, we present a novel dual-mode electrochemical biosensor capable of simultaneously detecting two clinical biomarkers─glycated albumin (GA) and glucose─a combination not previously reported on a single platform. While glucose reflects immediate glycemic status, GA provides insight into short- to intermediate-term control; thus, their concurrent detection enables a more holistic glycemic assessment, enhancing diagnostic accuracy. This simultaneous biosensor demonstrates competitive immunoassay and enzymatic detection. The biosensor integrates polyethylenimine-capped gold nanoparticles, graphene oxide, and two-dimensional bimetallic molybdenum tungsten disulfide onto two working area screen-printed carbon electrodes, enhancing sensitivity and performance. For glucose detection, glucose oxidase and ferrocene monocarboxylic acid function as the enzyme catalyst and redox mediator, while a competitive immunosensor employing methylene blue as a redox signal selectively identifies GA. Differential pulse voltammetry facilitates simultaneous high-precision biomarker quantification. Validated in a 50-fold diluted human serum, the biosensor exhibited remarkable detection ranges of 500-25,000 pg mL
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Registered trials
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