Evidence map›Paper›PMID 40443256›Full record

ReviewContact dermatitis2025

Requirements for Alternative In Vitro and In Silico Skin Models of Irritant and Allergic Contact Dermatitis.

Meital Portugal-Cohen, Warangkana Lohcharoenkal, Evelyn Kelemen, Inge Kortekaas Krohn, Shauni De Vriese, Danuta Gutowska-Owsiak, Ivone Jakasa, Dijana Furundžić, Anna Zalewska-Janowska, Sandrine Dubrac

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Contact dermatitis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Meital Portugal-CohenDermAb.io, Haifa, Israel.ORCID https://orcid.org/0000-0002-2454-1376
Warangkana LohcharoenkalEssity Hygiene and Health AB, Research and Development, Personal Care, Sweden.ORCID https://orcid.org/0000-0001-6541-1693
Evelyn KelemenDepartment of Medical Sciences, Dermatology and Venereology, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0002-8357-790X
Inge Kortekaas KrohnSkin Immunology & Immune Tolerance (SKIN) Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID https://orcid.org/0000-0003-3649-1131
Shauni De VrieseSkin Immunology & Immune Tolerance (SKIN) Research Group, Vrije Universiteit Brussel (VUB), Brussels, Belgium.ORCID https://orcid.org/0000-0003-2666-238X
Danuta Gutowska-OwsiakIntercollegiate Faculty of Biotechnology UG and MUG, University of Gdansk, Gdansk, Poland.ORCID https://orcid.org/0000-0003-4503-2279
Ivone JakasaLaboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.ORCID https://orcid.org/0000-0002-7961-4069
Dijana FurundžićStomatološka Ordinacija Furundžić Ordinacija, Belgrade, Serbia.
Anna Zalewska-JanowskaPsychodermatology Department, Chair of Pulmonology, Rheumatology and Clinical Immunology, Medial University of Lodz, Lodz, Poland.ORCID https://orcid.org/0000-0001-9900-7680
Sandrine DubracDepartment of Dermatology, Venereology and Allergology, Medical University of Innsbruck, Innsbruck, Austria.ORCID https://orcid.org/0000-0002-2936-8488

Funding

Austrian Research Fund P31662European Cooperation in Science and Technology CA21108 (NETSKINMODELS)National Science Centre UMO-2022/47/B/NZ5/01877
6 · The paper itself

Abstract

Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should require systematic surveillance. Large-scale testing is feasible by using organotypic and in silico skin models, which are becoming commonplace in industry and academic labs. In this work, we summarise the literature on models of contact dermatitis and provide insights on advantages, limitations and options for improvement.

Indexed as

Computer SimulationDermatitis, Allergic ContactDermatitis, IrritantIrritantsModels, BiologicalAllergensHumansIn Vitro TechniquesSkinAllergensIrritants3Rallergydermatitisirritationskin models

Identifiers

PMID40443256
PMCPMC12318915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.