ArticleMovement disorders : official journal of the Movement Disorder Society2025
A Convergent Pathway for Stimulation-Induced Dyskinesia Following Deep Brain Stimulation.
Article in Movement disorders : official journal of the Movement Disorder Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Adaptive deep brain stimulation for dynamic gait control in Parkinson's disease: a randomized feasibility trial.Nature medicine · 2026Trial
- Case Report: Effective management of a Meige syndrome patient with subthalamic stimulation-induced dyskinesia through timed stimulation programming of different contacts.Frontiers in human neuroscience · 2026Article
- Evaluation of DBS computational modeling methodologies using in-vivo electrophysiology in Parkinson's disease.Brain stimulationArticle
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Authors and funding
5 authors.
Funding
Abstract
backgroundStimulation-induced dyskinesias (SID) from deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are uncommon; however, they are increasingly recognized. Once considered transient and indicative of effective neuromodulation, SID are now seen as potential therapy-limiting side effects, akin to internal capsule activation. The mechanism and anatomical basis for SID remain poorly understood.
methodsWe conducted a retrospective study of individuals with Parkinson's disease with STN or GPi DBS who experienced SID in the dopaminergic medication OFF state during the monopolar review 1-month post-implantation.
resultsWe analyzed 137 monopolar stimulation observations (105 GPi, 32 STN). In the GPi cohort, discriminative fiber tract analysis showed a strong association between SID and the modulation of subthalamo-pallidal fibers. This correlation was confirmed using leave-one-out and five-fold cross-validation. We further validated this model by predicting SID in independent STN and GPi cohorts, with the GPi-based model accounting for significant variance in SID occurrence in both cohorts.
conclusionsSID from STN or GPi DBS likely shares a common pathway via subthalamo-pallidal connectivity. DBS modulation of these fibers correlates with SID, as confirmed by multiple cross-validation methods. These findings suggest that the fibers are part of a more extensive and yet-to-be-fully-characterized dyskinesia network. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
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