Observational studyMovement disorders clinical practice2025
Preserved Thermoregulation in Huntington's Disease: Insights from an Observational Case-Control Study.
Observational study in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundThermoregulation is critical for preventing hyperthermia during physical activity. In Huntington's disease (HD), research on possible thermoregulatory alterations has received little attention.
objectivesWe aimed to investigate and compare skin temperature differences before and after exercise between HD patients and healthy controls. Additionally, we aimed to evaluate potential correlations between thermoregulation, body composition, and HD severity.
methodsThis was a cross-sectional study. HD severity was assessed using the Total Functional Capacity and Unified HD rating scales. Skin temperature was assessed using thermographic infrared imaging of standardized 13 anatomical locations on the trunk and upper and lower extremities at baseline and after a treadmill test. Resting oxygen consumption was measured by indirect calorimetry. Differences between groups and correlation analyses between alterations in skin temperature and body composition, and HD severity were performed.
resultsWe included 14 patients with mild-moderate HD, mean age 60.5 (32-68) years, and 10 healthy-matched controls, mean age 56 (29-65) years. Although, similar thermoregulation capacity was observed between HD patients and controls, uniquely in HD, reduced temperature recovery after exercise was inversely correlated with body mass index (particularly fat mass), resting oxygen consumption, and CAG repeats, and positively correlated with age and quality of life (mental health domain).
conclusionAlthough thermoregulation appears to remain largely intact in patients with mild to moderate HD, it tends to decline with aging, CAG repeat expansion, and lower BMI, which may negatively impact overall well-being in HD patients. However, further research with larger sample sizes is essential to confirm these results.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.