ArticleGeriatrics & gerontology international2025
Impaired insulin receptor function alters psychiatric behaviors without affecting circadian rhythms in a mouse model of Alzheimer's disease.
Article in Geriatrics & gerontology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Peripheral Insulin Resistance and Alzheimer's Disease: Possible Mediators Including Extracellular Vesicles.Geriatrics & gerontology international · 2026Review
- Impaired insulin receptor function alters psychiatric behaviors without affecting circadian rhythms in a mouse model of Alzheimer's disease.Geriatrics & gerontology international · 2025Article
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3 authors.
Funding
Abstract
aimBehavioral and psychological symptoms of dementia (BPSD) are a cause of reduced quality of life in patients with Alzheimer's disease (AD) and their caregivers. In this study, we examined the influence of insulin resistance, a risk factor for AD, on BPSD in AD pathology and related adrenergic and dopaminergic gene expressions in a mouse model.
methodsConstitutive knock-in mice with the P1195L mutation in the insulin receptor (IR-KI mice) and those with a mutated amyloid precursor protein (App
resultsAPP/IR-dKI mice exhibited significantly longer immobilization in the forced swimming test and longer time spent on the light side in the light/dark box test than did APP-KI mice. No differences in circadian rhythms and physical activity in the dark and light phases were observed between APP-KI and APP/IR-dKI mice. Regarding gene expression of Adr1a1, Adr1a2, Adr1ad, Drd1, and Drd2 in the cortical region, there were no differences between APP-KI and APP/IR-dKI mice. These results suggest that APP/IR-dKI mice exhibit enhanced depression and suppressed anxiety compared with APP-KI mice, without mediation by the alteration of adrenergic or dopaminergic receptors.
conclusionsInsulin resistance could enhance depression and suppress anxiety in relation to BPSD in AD. Geriatr Gerontol Int 2025; 25: 967-971.
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