Evidence map›Paper›PMID 40443012›Full record

ArticleJournal of managed care & specialty pharmacy2025

Optimization of oncology biomarker testing in managed care: Best practices and consensus recommendations from an AMCP Market Insights program.

Diana Brixner, Terry Richardson, Catherine M Lockhart, Scott Ramsey, John Fox, Daryl Pritchard, Howard Mcleod, Laura Bobolts, Brian Bourbeau, Erin Crum

Abstract readConsensus Statement
In one paragraph

Article in Journal of managed care & specialty pharmacy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Findings from the 2025 AMCP Foundation Symposium: Health Optimization 2.0.Journal of managed care & specialty pharmacy · 2026
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Diana BrixnerDepartment of Pharmacotherapy, University of Utah, Salt Lake City.
Terry Richardson
Catherine M LockhartImpact Education, Blue Bell, PA; AMCP and Biologics & Biosimilars Collective Intelligence Consortium, Asheville, NC.
Scott RamseyFred Hutchinson Cancer Center, Seattle, WA.
John FoxIllumina, Grand Rapids, MI.
Daryl PritchardPersonalized Medicine Coalition, Washington, DC.
Howard McleodUtah Tech University, St. George.
Laura BoboltsOncoHealth, Plantation, FL.
Brian BourbeauAmerican Society of Clinical Oncology, Alexandria, VA.
Erin CrumMcKesson and The US Oncology Network, Boise, ID.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision medicine in oncology using actionable molecular biomarkers to guide treatment selection has been associated with favorable outcomes; however, many potentially eligible patients do not receive it. This Academy of Managed Care Pharmacy Market Insights program sought to characterize unmet needs in biomarker testing among managed care stakeholders, to develop best practice and consensus recommendations to support addressing these needs, and to gain insights on potential quality measures related to biomarker testing. The program used a modified Delphi process and included in-depth interviews with expert panelists, a national survey of managed care professionals, and a consensus survey of experts. Areas of unmet need in biomarker testing identified were education, guidelines and protocols, timeliness, process, and equity. Twenty-two best practices were suggested by managed care experts and other stakeholders; 9 of these best practices achieved consensus. These consensus recommendations addressed biomarker test ordering and test performance, treatment decisions based on biomarker testing, cost-effectiveness of biomarker testing, and health disparities in access to biomarker testing. Opportunities for education and improvements in infrastructure to implement these recommendations were identified. Further investigation is needed to develop quality measures; although, valuable insights were gained.

Indexed as

Biomarkers, TumorManaged Care ProgramsMedical OncologyNeoplasmsPrecision MedicineCost-Benefit AnalysisDelphi TechniqueHumansPractice Guidelines as TopicSurveys and QuestionnairesBiomarkers, Tumor

Identifiers

PMID40443012
PMCPMC12123195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.