Evidence map›Paper›PMID 40442917›Full record

SynthesisCurrent neuropharmacology2026

Early-Life Microbiome and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis.

Md Fakruddin, Tasbir Amin, Md Asaduzzaman Shishir, Rameesa Maliha Jameel, Mubashshir Muntaha Bari, Nashia Farzana Shameem, Amana Hossain, Nusrat Jerin, Shahnewaj Bin Mannan, Jinath Sultana Jime and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Md FakruddinDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Tasbir AminDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Md Asaduzzaman ShishirDepartment of Microbiology, Dhaka International University, Satarkul, Badda, Dhaka, Bangladesh.
Rameesa Maliha JameelDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Mubashshir Muntaha BariDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Nashia Farzana ShameemDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Amana HossainDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Nusrat JerinDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Shahnewaj Bin MannanH Lee Moffitt Cancer Center and Research Institute 12902 USF Laurel Dr. Tampa, Florida, USA.
Jinath Sultana JimeDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.
Nayeema BulbulDepartment of Biochemistry & Microbiology, North South University, Bashundhara, Dhaka, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThis systematic review intends to find out how neurodevelopmental disorders, including Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD), are influenced by the gut microbiota throughout early childhood. The study looks at the variety and types of microbes that a child is exposed to, the particular microbiome profiles associated with neurodevelopmental outcomes, and the molecular processes that underlie these relationships.

methodsWe performed a thorough search of PubMed, Scopus, the WHO Global Health Library (GHL), and ISI Web of Science. After screening 2,744 original studies based on predetermined eligibility criteria, 19 studies were included. Microbial groupings, presence (high/low), and related neurodevelopmental disorders were among the primary areas of data extraction. The methodological quality of the studies was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS).

resultsThe investigated literature repeatedly showed a strong correlation between dysbiosis of the gut microbiota and neurodevelopmental disorders. Cases of ASD were associated with both a high number of Clostridium species and a low number of Bifidobacterium species. On the other hand, a Low number of E. coli and a high number of the class Clostridia, phylum Firmicute, genus Bifidobacterium, and Akkermansia, as well as the species Listeria monocytogenes, Toxoplasma gondii, Streptococcus mutans, and Mycobacterium tuberculosis have been linked to ADHD. The NOS evaluation showed variation in the quality of the methodology; some studies had high scores, suggesting sound technique, while other studies had lower scores, indicating serious methodological flaws.

conclusionThe results highlight the potential impact of the gut microbiome throughout early life on neurodevelopmental outcomes, indicating that microbial imbalances may play a role in the onset of disorders like ASD and ADHD. However, to improve the quality of data, larger-scale longitudinal studies would be required.

Indexed as

Autism Spectrum DisorderGastrointestinal MicrobiomeNeurodevelopmental DisordersAttention Deficit Disorder with HyperactivityChildDysbiosisHumansAttention Deficit Hyperactivity Disorder (ADHD)Autism Spectrum Disorder (ASD)Early-life microbiomegut-brain axisneurodevelopmental disorderssystematic review.

Identifiers

PMID40442917
PMCPMC13054730

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.