Evidence map›Paper›PMID 40442881›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Feasibility of lifestyle interventions for cognition in adults with low education.

Daniel O Clark, Huiping Xu, Christy C Tangney, Annie W Lin, Shannon L Risacher, Andrew J Saykin, Robert V Considine, Holly J Garringer, Lyndsi Moser, Amy Carter and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03419052 (MIND Food and Speed of Processing Training in Older Adults With Low Education, The MINDSpeed Alzheimer's Disease Prevention Pilot Trial), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03419052 nacompletednot on this map

MIND Food and Speed of Processing Training in Older Adults With Low Education, The MINDSpeed Alzheimer's Disease Prevention Pilot Trial

TypeinterventionalSponsorIndiana UniversityRan2019 to 2024Enrolled212ConditionsLow Education, Cognition, Cognitive Training, PolyphenolsArmsSpeed of processing training, MIND foods, Cognitive training control, Control foods
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Feasibility of lifestyle interventions for cognition in adults with low education.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Daniel O ClarkDepartment of Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Huiping XuDepartment of Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Christy C TangneyDepartment of Clinical Nutrition, Rush University Medical Center, Chicago, Illinois, USA.
Annie W LinThe Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
Shannon L RisacherCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Andrew J SaykinCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Robert V ConsidineDepartment of Medicine, Division of Endocrinology, Indianapolis, Indiana, USA.
Holly J GarringerIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Lyndsi MoserDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Amy CarterEskenazi Health, Indianapolis, Indiana, USA.
Catherine M MillerDepartment of Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Briana SpragueDepartment of Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Christopher M CallahanDepartment of Medicine, Division of General Internal Medicine and Geriatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Frederick W UnverzagtIndiana Alzheimer's Disease Research Center, Indiana University School of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4M
MIND Food and Speed of Processing Training in Older Adults with Low Education, The MINDSpeed Alzheimer's Disease Prevention Pilot TrialR01AG052439 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI CLARK, DANIEL O, UNVERZAGT, FREDERICK W. · 2017 to 2022
$3.5M
NIA NIH HHS R01 AG052439NIA NIH HHS R01AG052439NIDDK NIH HHS P30 DK097512
6 · The paper itself

Abstract

introductionWe report the feasibility and cognitive outcomes of a stage 1b randomized trial testing 3 months of home-delivered high polyphenol snacks (e.g., nuts, berries) and online speed of processing training among older adults with 12 or fewer years of education.

methodsOne hundred eighty participants were randomized to polyphenol-rich snacks and online cognitive training, polyphenol snacks and online control games, control snacks and cognitive training, or control snacks and control games. The outcomes were feasibility of recruitment, retention, and adherence (RRA) and change in a cognitive composite score.

resultsFeasibility goals for RRA were met. Improvements in the cognitive score were evident in all groups (effect sizes ranged from 0.15-0.35) but improvements did not differ significantly between arms. DISCUSSION: Dementia prevention trials with longer intervention and follow-up focused on adults with limited formal education should be considered given the observed cognitive gains in those with elevated risk. CLINICAL

trial registrationClinicalTrials.gov (NCT03419052). HIGHLIGHTS: The study focused on adults with low education; a group with a high risk for cognitive decline. Two interventions were tested in a randomized trial design that included two controls. Nutrition intervention was designed with input from adults with limited education. PRIMARY OUTCOME: A cognitive composite score was formed from five established cognitive tests. The study establishes the feasibility of dementia prevention targeting adults with low education.

Indexed as

CognitionEducational StatusLife StyleSnacksAgedDementiaFeasibility StudiesFemaleHumansMaleMiddle AgedNeuropsychological TestsAlzheimer's diseasecognitioncognitive trainingpolyphenolsrandomized controlled trial

Identifiers

PMID40442881
PMCPMC12122255

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.