Evidence map›Paper›PMID 40442783›Full record

ReviewStem cell research & therapy2025

Unveiling the dynamic drivers: phase separation's pivotal role in stem cell biology and therapeutic potential.

Pei Lin, Yunfan Lin, Ye Lu, Xu Chen, Zihao Zhou, Xinyuan Zhao, Li Cui

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pei Lin *Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Yunfan Lin *Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Ye LuStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Xu ChenStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Zihao ZhouStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China.
Xinyuan ZhaoStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China. zhaoxinyuan1989@smu.edu.cn.
Li CuiStomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, 510280, Guangdong, China. licui@smu.edu.cn.ORCID http://orcid.org/0000-0001-9814-6945

Funding

National Natural Science Foundation of China 81901006National Natural Science Foundation of China 82372905
6 · The paper itself

Abstract

Phase separation is fundamental for cellular organization and function, profoundly impacting a range of biological processes from gene expression to cellular signaling pathways, pivotal in stem cell biology. This review explores the primary types of phase separation and their mechanisms, emphasizing how phase separation is integral to maintaining cellular integrity and its significant implications for disease progression. It elaborates on current insights into how phase separation influences stem cell biology, discussing the challenges in translating these insights into practical applications. These challenges stem from the complex dynamics of phase separation, the need for advanced imaging techniques, and the necessity for real-time, in situ analysis within living systems. Addressing these challenges through innovative methodologies and gaining a deeper understanding of the molecular interactions that govern phase separation in stem cells are essential for developing precise, targeted therapies. Ultimately, advancing our understanding of phase separation could transform stem cell-based therapeutic approaches, opening up novel strategies for disease treatment and advancements in regenerative medicine.

Indexed as

Stem CellsAnimalsHumansPhase SeparationRegenerative MedicineSignal TransductionPhase separationStem cell biologyTherapeutic potential

Identifiers

PMID40442783
PMCPMC12123740

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.