Evidence map›Paper›PMID 40442696›Full record

ArticleVirology journal2025

An inactivated influenza D virus vaccine protects guinea pigs from infections and contact transmission caused by homologous challenge.

Zhipeng Dong, Pengyang Lu, Yue Feng, Hongbo Gao, Wentao Wan, Tiecheng Wang, Xianzhu Xia, Weiyang Sun, Yuwei Gao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhipeng DongChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Pengyang LuHenan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Yue FengCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, China.
Hongbo GaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Wentao WanCollege of Veterinary Medicine, Shanxi Agricultural University, Jinzhong, 030801, China.
Tiecheng WangChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Xianzhu XiaChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China.
Weiyang SunChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China. sunweiyang1987@163.com.
Yuwei GaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, State Key Laboratory of Pathogen and Biosecurity, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun, 130122, China. dawei1105@foxmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza D virus (IDV) was first isolated from pigs in 2011 which caused the bovine respiratory disease and economic losses. This study aimed to develop an inactivated vaccine to protect against IDV using guinea pigs as an animal model. Vaccinated guinea pigs exhibited seroconversion with hemagglutination inhibition titers ranging from 1: 320 to 1: 640 and neutralizing antibody levels reaching 1: 2560 after booster immunity. In the vaccinated guinea pigs, viral titers were detected in the nasal lavage fluids from days one to seven, showing a significant difference from the control group. Peak viral shedding of approximately 10

Indexed as

Influenza VaccinesOrthomyxoviridae InfectionsThogotovirusAnimalsAntibodies, NeutralizingAntibodies, ViralDeltainfluenzavirusDisease Models, AnimalFemaleGuinea PigsHemagglutination Inhibition TestsVaccines, InactivatedVirus SheddingAntibodies, NeutralizingAntibodies, ViralInfluenza VaccinesVaccines, InactivatedContact transmissionGuinea pigsInactivated vaccineInfluenza D virus

Identifiers

PMID40442696
PMCPMC12121277

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.