ReviewAnnals of general psychiatry2025
Inflammatory markers and suicidal behavior: A comprehensive review of emerging evidence.
Review in Annals of general psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- TNF-α levels in first-episode, drug-naïve patients with major depressive disorder: a case-control study and meta-analysis.BMC psychiatry · 2026Pooled it
- Employment Status Shapes the Link between Serum Tumor Necrosis Factor and Suicidal Ideation in Patients with Acute Coronary Syndrome: Evidence from an Independent Clinical Cohort.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026Article
- Pursuing the elusive biosignature for suicide: a decennial update.Molecular psychiatry · 2026Review
- Inflammation and treatment strategies for suicidal behavior.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2026Review
- Elevated serum calprotectin levels in major depressive disorder: no evidence of association with S100A9 rs3014866 polymorphism.BMC psychiatry · 2026Article
- Associations of smoking and alcohol consumption with suicidality in major depressive disorder: a cross-sectional analysis of UK Biobank.BMC psychiatry · 2026Article
- Beyond Suicidal Ideation: Identifying High-Risk University Students Through Depression, Sleep Disturbance, and Impulsivity-A Cross-Sectional Secondary Analysis.Journal of clinical medicine · 2026Article
- Inflammatory and Metabolic Blood Parameters Associated with Aggression, Impulsivity, and Suicide Risk Among Male Patients with Antisocial Personality Disorder in a Forensic Psychiatry Unit in Turkey: A Cross-Sectional Comparative Study.Diagnostics (Basel, Switzerland) · 2026Article
- Two-week prevalence and correlates of suicidal ideation among first-visit general-hospital psychiatric outpatients: a cross-sectional study using the PHQ-9 and EPQ.BMC psychiatry · 2026Article
- Identification of metabolism and inflammation-related biomarkers and potential drugs for schizophrenia based on comprehensive bioinformatics and machine learning.BMC psychiatry · 2026Article
- Beyond mental disorders: The role of child maltreatment in childhood suicidal behaviour.The Australian and New Zealand journal of psychiatry · 2026Article
- Associations of clustered unhealthy lifestyle behaviors with comorbidity of anxiety and depression among adolescents.BMC psychiatry · 2026Article
- Serum Claudin-5 and Peripheral Inflammation in Major Depressive Disorder: A Case-Control Study with Focus on Suicidal Ideation.Alpha psychiatry · 2026Article
- Latent Profiles of Suicide Risk in University Students: a Multidimensional Model Integrating sleep, mood, interpersonal, and Behavioral Factors.The Psychiatric quarterly · 2026Article
- Associations of interoceptive sensibility and inflammatory markers with suicidal ideation in major depressive disorder.BMC psychiatry · 2026Article
- Inflammation and suicide risk in adolescents with self-injury: Expanding the role of mental health nursing.World journal of psychiatry · 2026Article
- Article
- Biomarkers Identifying Tendency to Suicide (BITS): detection of biomarkers in adolescents with suicidal ideation or suicidal behavior for early prevention or intervention. A prospective cohort study.Frontiers in human neuroscience · 2026Article
- Ceramides and neuroinflammation as immunometabolic drivers and biomarkers of major depressive disorder, treatment-resistant depression, and suicidal vulnerability.Frontiers in pharmacology · 2026Review
- Inflammatory indices are associated with non-suicidal self-injury in adolescents with major depressive disorder.BMC psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSuicidal behavior represents a significant public health challenge, and identifying biological markers associated with its risk is critical for prevention and intervention. Emerging evidence suggests a link between inflammation and suicidality, highlighting the role of inflammatory markers as potential biomarkers and therapeutic targets.
methodsWe conducted a systematic search across four electronic databases, including PubMed, Web of Science, EMBASE, and PsycINFO, to identify studies examining the association between inflammatory markers (e.g., C-reactive protein, interleukin-6, tumor necrosis factor-alpha) and suicidal ideation or behavior.
results31 studies met the inclusion criteria. Elevated levels of inflammatory markers were consistently associated with an increased risk of suicidal behavior across diverse populations. This relationship's mechanisms likely involve cytokine-mediated alterations in neurotransmitter systems, neuroplasticity, and stress response pathways. Though robust clinical trials are scarce, preliminary evidence suggests that anti-inflammatory interventions may reduce suicidality.
conclusionsInflammation appears to play a significant role in the pathophysiology of suicidal behavior, offering promising avenues for biomarker development and novel therapeutic strategies. Future research should prioritize longitudinal studies, standardized methodologies, and exploration of personalized anti-inflammatory treatments to better elucidate the inflammation-suicidality link and enhance clinical applicability.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.