ArticleBMC pregnancy and childbirth2025
ITGB3 and associated molecules as critical biomarkers in Cesarean Scar Pregnancy.
Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Increased Endometrial CD38 and CD138 Positivity in Women with Ectopic Pregnancy History: A Retrospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Fedratinib inhibits ovarian cancer progression by downregulating QPCT expression.Discover oncology · 2025Article
- Multidisciplinary team management of caesarean scar ectopic pregnancy progressing to a live birth and caesarean hysterectomy at 34 weeks: A case report.Case reports in women's health · 2025Article
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8 authors.
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Abstract
backgroundCesarean scar pregnancy (CSP) is a life-threatening condition with a rising incidence in China. The pathogenesis of CSP remains poorly understood, partly due to the limited availability of comprehensive datasets constrained by spatiotemporal factors.
objectiveThis study aimed to explore key regulatory molecules and mechanisms involved in CSP through a multi-omics approach.
methodsProteomic analysis was performed on decidual and villous tissues from clinical patients (n = 6, including 3 CSP cases and 3 controls). Gene expression datasets (n = 9) were obtained from the GEO and SRA databases. Bioinformatics analyses were conducted using DAVID, Metascape, and STRING, with transcription factor prediction performed via the JASPAR database. Data analysis was conducted using SPSS 27, with a significance threshold set at P < 0.05.
resultsCSP shared differentially expressed genes (DEGs) with cesarean delivery (CD) and embryo implantation (EI). Enrichment analysis revealed that biological processes and KEGG pathways related to adhesion, with Integrin Subunit Beta 3 (ITGB3), Integrin Subunit Alpha 2b (ITGA2B), and Vitronectin (VTN) playing significant roles. ITGB3 expression was significantly downregulated following CD compared to spontaneous delivery, followed by upregulation in subsequent pregnancies. The transcription factor GATA4 was identified as a key regulator of ITGB3, potentially contributing to CSP pathogenesis.
conclusionOur findings suggest that CSP development is closely associated with CD and EI, with ITGB3 and its regulatory network playing a crucial role. GATA4-mediated regulation of ITGB3 may represent an important molecular mechanism contributing to CSP formation.
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