Evidence map›Paper›PMID 40442581›Full record

ArticleBMC infectious diseases2025

Molecular epidemiology of hepatitis B virus from blood samples obtained from persons in Enugu and Nasarawa States, Nigeria.

Kingsley Andrew Egbe, Anthony C Ike, Olusola Anuoluwapo Akanbi, Richard Olulowo Ojedele, Khadijah Isa Imam, Chimaobi Chukwu, Friday Egbe, Edith Silas Ekwom, Nse F Unam, Ikeata Kenneth Chukwuemeka

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kingsley Andrew EgbeDepartment of Microbiology, Faculty of Biological Sciences, University of Nigeria Nsukka, Nsukka, Enugu State, Nigeria.
Anthony C IkeDepartment of Microbiology, Faculty of Biological Sciences, University of Nigeria Nsukka, Nsukka, Enugu State, Nigeria. anthonyc.ike@unn.edu.ng.
Olusola Anuoluwapo AkanbiGenomics Laboratory, Nigerian Centre for Disease Control, National Reference Laboratory, Gaduwa, Abuja, Nigeria.
Richard Olulowo OjedeleGenomics Laboratory, Nigerian Centre for Disease Control, National Reference Laboratory, Gaduwa, Abuja, Nigeria.
Khadijah Isa ImamGenomics Laboratory, Nigerian Centre for Disease Control, National Reference Laboratory, Gaduwa, Abuja, Nigeria.
Chimaobi ChukwuGenomics Laboratory, Nigerian Centre for Disease Control, National Reference Laboratory, Gaduwa, Abuja, Nigeria.
Friday EgbePublic Health Department, Federal Capital Territory Administration, Abuja, Nigeria.
Edith Silas EkwomDepartment of Microbiology, Faculty of Science, Cross River University of Technology, Calabar, Cross River State, Nigeria.
Nse F UnamHaematology Unit, Federal Staff Clinic Gwarinpa, Abuja, Nigeria.
Ikeata Kenneth ChukwuemekaGenomics Laboratory, Nigerian Centre for Disease Control, National Reference Laboratory, Gaduwa, Abuja, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatitis B virus (HBV) infection remains a major global health concern, with a high burden in countries like Nigeria. This study aimed to investigate the molecular epidemiology of HBV by identifying circulating genotypes and detecting antiviral-resistant mutations in samples from selected communities in Enugu and Nasarawa States, Nigeria. Sample (plasma and serum) quality was evaluated after prolonged storage under freeze-thaw conditions using Qubit 4 fluorometer and Nanodrop One spectrophotometer. High-quality samples underwent molecular characterization and Sanger sequencing for HBV-positive cases. Of the 67 samples analyzed, seven were sequenced: two from Enugu and four from Nasarawa belonged to genotype E, while one from Nasarawa was genotype A. No antiviral resistance mutations were identified. This study provides valuable molecular data contributing to our understanding of HBV epidemiology in Nigeria.

Indexed as

Hepatitis BHepatitis B virusAdolescentAdultDNA, ViralDrug Resistance, ViralFemaleGenotypeHumansMaleMiddle AgedMolecular EpidemiologyMutationNigeriaPhylogenyYoung AdultDNA, ViralAntiviral resistanceEnugu stateGenotypeHepatitis B virusMolecular epidemiologyNasarawa state

Identifiers

PMID40442581
PMCPMC12123755

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.