ArticleCognitive, affective & behavioral neuroscience2026
Obsessive-compulsive symptoms predict increased fronto-parahippocampal synchronisation during thought suppression.
Article in Cognitive, affective & behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThought suppression is suggested as a causal factor in obsessive-compulsive disorder (OCD), as it can lead to an increase in intrusive thoughts. However, the neural mechanisms through which obsessive-compulsive symptoms (OCS) influence thought suppression, particularly in the context of preferential processing of negatively valenced stimuli, remains unclear. We hypothesized that OCS would predict increased inhibitory communication between frontal and parahippocampal neurocircuitry during the suppression of negative words. Additionally, we tested an exploratory analysis to see whether this was mediated by preferential processing of these stimuli.
methodsEEG was recorded from 47 participants tasked with directed forgetting of negative and neutral words. Data from 38 of these participants were analyzed. We examined the influence of OCS on fronto-parahippocampal beta-1 (13-18 Hz) synchronization during a Directed Forgetting task. An exploratory analysis of the mediating role of stimulus processing bias, measured via the late positive potential following the word stimulus, was assessed using a mediated moderation model.
resultsObsessive-compulsive symptoms predicted enhanced fronto-parahippocampal beta-1 synchronisation when instructed to forget negative words. The moderating effect of valence was mediated by preferential processing of negative stimuli, as indicated by increased late positive potential.
conclusionsHealthy individuals with relatively high OCS exhibit compensatory connectivity between frontal and parahippocampal regions when attempting to suppress negative emotional stimuli. Exploratory analysis showed this compensatory activity is influenced by both preferential processing of negative stimuli and the severity of OCS, providing preliminary evidence of a neural mechanism that may contribute to the persistence of intrusive thoughts in OCD.
Indexed as
Identifiers
40442545What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.