ArticlePituitary2025
Muscle dysfunction is associated with poor quality of life in long-term controlled patients with acromegaly.
Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026Review
- The acromegaly patient experience: burden of treatment and quality of life.The Journal of clinical endocrinology and metabolism · 2026Review
- Recent progress in the understanding of psychological complications of acromegaly: toward a longitudinal clinical phenotype.Pituitary · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAcromegaly (ACRO) leads to significant physical and psychological morbidity. Although patients often report persistent muscle dysfunction and impaired quality of life (QoL) after hormone control, the relationship between these two factors remains largely underexplored. Our objective was to investigate the association between muscle function parameters and QoL in long-term controlled ACRO patients.
methodsWe studied 36 patients with ACRO (14 males, 22 females; mean age 54 ± 8 years) with controlled GH/IGF-I excess, defined as normalized IGF-I levels and suppressed GH concentrations after an OGTT, during a mean (± SD) of 8 (4) years. Muscle function was assessed using gait speed (GS), timed up and go (TUG), handgrip strength (HGS), and the 30-second chair-to-stand test. QoL was evaluated using the AcroQoL and SF-36 questionnaires.
resultsPoor muscle performance, particularly on GS and TUG, was significantly associated with reduced QoL scores on physical, psychological, and social domains of AcroQoL and SF-36 questionnaires. In women, mobility limitations were linked to impaired self-image and physical functioning. In men, reduced muscle strength and mobility were associated with broad QoL alterations on physical and emotional dimensions. These findings highlight the significant impact of muscle dysfunction on both physical performance perception and psychosocial well-being in ACRO patients.
conclusionMuscle dysfunction in long-term controlled ACRO patients negatively affects QoL, underscoring the need for routine functional assessments and targeted rehabilitation strategies.
Indexed as
Identifiers
40442526What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.