Evidence map›Paper›PMID 40442513›Full record

ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025

One-way self-expanding rods for early onset neuromuscular scoliosis: a two-year follow-up of an international cohort.

Anne Mareille Post, Mathilde Gaume, Barend Jan van Royen, Esther Janssen, Kris Lundine, Michael Johnson, Petre Neagoe, Moyo Kruyt, Louis Boissiere, Jean-Paul Kaleeta Maalu and 8 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anne Mareille PostAmsterdam University Medical Centers, Amsterdam, Netherlands. a.m.post@amsterdamumc.nl.
Mathilde GaumeHôpital Armand-Trousseau, Paris, France.
Barend Jan van RoyenAmsterdam University Medical Centers, Amsterdam, Netherlands.
Esther JanssenRadboud University Nijmegen Medical Centre, Nijmegen, Netherlands.
Kris LundineMurdoch Children's Research Institute, Melbourne, Australia.
Michael JohnsonMurdoch Children's Research Institute, Melbourne, Australia.
Petre NeagoeUniversity Hospital of Montpellier, Montpellier, France.
Moyo KruytUniversity Medical Center Utrecht, Utrecht, Netherlands.
Louis BoissiereCentre Hospitalier Universitaire de Bordeaux, Bordeaux, France.
Jean-Paul Kaleeta MaaluQueen Fabiola Children's University Hospital, Brussels, Belgium.
Jeroen RenkensErasmus MC - Sophia Children's Hospital, Rotterdam, Netherlands.
Moritz C DemlDepartment of Orthopaedics and Trauma Surgery, Inselspital Bern, University Hospital Bern, University Bern, Bern, Switzerland.
Agnita StadhouderAmsterdam University Medical Centers, Amsterdam, Netherlands.
Federico SollaLenval University Children's Hospital, Nice, France.
Samuel SchaibleDepartment of Orthopaedics and Trauma Surgery, Inselspital Bern, University Hospital Bern, University Bern, Bern, Switzerland.
Casper TabelingUniversity Medical Center Utrecht, Utrecht, Netherlands.
Julia MielenbrinkUniversity Hospital of Montpellier, Montpellier, France.
Lotfi MiladiHôpital Necker-Enfants Malades, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionFusionless surgical techniques are increasingly used to treat patients with early-onset and juvenile neuromuscular scoliosis (NMS) to correct and stabilize the scoliotic curves while preserving natural growth. This study aimed to evaluate clinical and radiological outcomes two years after minimally invasive surgery using a commercially available CE-certified (Conformité Européenne) one-way self-expanding rod (OWSER) system in a large international cohort of patients with NMS.

methodsPatients who underwent surgical treatment with the OWSER system for NMS correction, with a two-year follow-up were retrospectively included and analyzed for two-year follow-up. The surgery consisted of a bilateral OWSER system from the upper cervico-thoracic spine to the pelvis using a minimally invasive approach. Radiological parameters, including Cobb angle, pelvic obliquity, thoracic kyphosis, lumbar lordosis and spinal length (T1-S1), were assessed preoperatively and at follow-up. Clinical performance was based on complications and unplanned reoperations.

resultsSeventy-six patients from ten international centers were included. The mean age at surgery was 9.6 ± 2.5 years. Diagnoses included cerebral palsy (n = 23), spinal muscular atrophy (n = 14), and other neuromuscular syndromes (n = 39). Mean Cobb angle improved from 80 ± 25° preoperative to 39.7 ± 20.9° at 2-years follow-up, mean pelvic obliquity improved from 19 ± 12° to 6.4 ± 6.2° and mean preoperative kyphosis decreased from 44 ± 24° to 32.9 ± 14°. Segment T1-S1 increased 5.9 cm peri-operatively and patients showed a mean growth after instrumentation from 34 ± 5.cm to 35 ± 5.2 cm in two years due to the OWSER system. Procedure related complications occurred in 22 patients (29%): twelve surgical site infections, and 20 mechanical and alignment-related complication, resulting in 27 revision surgeries in 20 patients (26%).

conclusionThe OWSER system provides stable correction of Cobb angle at two-year follow-up while allowing continued spinal growth in juvenile or early-onset NMS. Despite a notable complication rate, this technique offers a reliable treatment for NMS patients. We continue to follow-up these patients as long-term outcomes are necessary to confirm these encouraging results.

Indexed as

Neuromuscular DiseasesScoliosisSpinal FusionAdolescentChildFemaleFollow-Up StudiesHumansMaleMinimally Invasive Surgical ProceduresRetrospective StudiesThoracic VertebraeTreatment OutcomeBipolar techniqueEarly onset scoliosisGrowing rodsMinimally invasive surgeryNeuromuscular scoliosisSelf-expanding rod

Identifiers

PMID40442513

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.