SynthesisEvidence-based dentistry2025
Dentures and the oral microbiome: Unraveling the hidden impact on edentulous and partially edentulous patients - a systematic review and meta-analysis.
Synthesis in Evidence-based dentistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Review
- Tregs and persistentFrontiers in oral health · 2026Article
- Denture-associated oral microbiome in dentate and edentulous older adults living in long-term care facilities.Journal of oral microbiology · 2026Article
- Effectiveness of Ozone Treatment, Ultrasonic Treatment, and Ultraviolet Irradiation in RemovingMaterials (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis systematic review and meta-analysis evaluate the impact of edentulism and denture use on the oral microbiome, focusing on microbial diversity, colonization and biofilm formation in completely and partially edentulous patients.
methodsA comprehensive search was conducted across five databases (PubMed-Medline, Scopus, Embase, Lilacs, and Google Scholar) until June 1, 2024. Randomized and non-randomized clinical trials, observational studies, and cohort studies were included. Data extraction and risk of bias assessment followed PRISMA guidelines. Meta-analysis was performed using STATA and R software with a random effects maximum likelihood model. Microbial co-occurrence networks, heatmaps, and longitudinal trends were analyzed, with heterogeneity assessed using Higgin's I² (substantial heterogeneity defined as I² > 50%).
resultsThirty-two studies met the inclusion criteria. The oral microbiome in edentulous patients differed significantly from dentate individuals, influenced by denture materials, design, and time. Veillonella abundance in acrylic complete dentures was 13.63% (95% CI = -0.04, 27.29), I² = 90.98%, compared to 49.10% (95% CI = -29.62, 115.81), I² = 99.47% in dentate patients. Candida albicans increased over time in acrylic dentures, from 63.13% (95% CI = 48.93, 77.33), I² = 99.84% after insertion to 344.72 CFU/ml × 10² (95% CI = 139.19, 550.24), I² = 98.30% at nine months. Streptococcus mutans in CAD/CAM dentures increased from 45.54 CFU/ml × 10² (95% CI = 33.82, 57.25), I² = 87.26% at three months to 125.22 CFU/ml × 10² (95% CI = 38.25, 212.18), I² = 97.89% at nine months. Co-occurrence networks revealed strong Candida albicans-Streptococcus mutans synergy, while Fusobacterium nucleatum showed antagonistic interactions. Heatmaps demonstrated microbial dysbiosis in denture stomatitis cases, with increased Porphyromonas gingivalis and Candida albicans and reduced commensals. Longitudinal analyses highlighted the progressive dominance of opportunistic pathogens, emphasizing the need for early and consistent hygiene interventions.
conclusionDenture wearers exhibit distinct microbial communities influenced by biofilm formation, denture materials, and hygiene practices. Findings highlight the importance of antimicrobial denture materials and effective cleaning protocols in managing microbial colonization. Given high heterogeneity, standardized methodologies are essential for future research. Frequent professional cleaning and individualized hygiene strategies are necessary to prevent denture-associated infections and maintain oral health.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.