Evidence map›Paper›PMID 40442492›Full record

ReviewSpinal cord2025

Evaluating therapeutic effects of exoskeletons and FES in SCI: integrative review of the literature.

Rachel Y Kim, Olivia M Biller, M J Mulcahey

Abstract readReview
In one paragraph

Review in Spinal cord, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rachel Y KimCenter for Outcomes and Measurement, Jefferson College of Rehabilitation Sciences, Thomas Jefferson University, Philadelphia, USA. rxk076@jefferson.edu.ORCID 0000-0001-6068-4967
Olivia M BillerJohnson & Johnson, Raritan, USA.ORCID 0000-0001-9832-1838
M J MulcaheyCenter for Outcomes and Measurement, Jefferson College of Rehabilitation Sciences, Thomas Jefferson University, Philadelphia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFunctional electrical stimulation and exoskeletons provide direct functional ability but may also have therapeutic effects that improve function when they are turned off or removed.

objectiveThis integrative review aimed to identify functional clinical outcome assessments used to assess therapeutic effects in rehabilitation technologies for persons with spinal cord injuries, to examine the National Institute of Neurological Disorders and Stroke Common Data Elements recommendation level for SCI for each COA, and determine which COAs distinguish between recovery of function and function from compensation.

methodsA literature search identified interventional SCI studies using FES and exoskeletons (n = 1006). Text screens resulted in a sample (n = 56) organized by level of evidence, COAs with their measurement properties, type of intervention with involved limbs, the NINDS CDE recommendation level, and if the COAs distinguished recovery from compensation.

results56 articles met inclusion criteria. 31 studies involved exoskeletons, 23 studies involved FES, and 2 studies involved both FES and exoskeleton. Within those 56 articles, 38 COAs were identified across all studies, including different versions of the same COA as separate measures. Of these 38 COAs, 24 were PerfOs and 7 were PROs. The most used COAs did not differentiate recovery from compensation. However, 3 COAs were identified as able to discriminate recovery from compensation.

conclusionsStudies on FES and exoskeletons in SCI have precedent to examine therapeutic effects using a variety of functional COAs. Clinical trials in SCI would benefit from COAs with interval scales that assess therapeutic effects that differentiate between recovery and compensation.

Indexed as

Electric Stimulation TherapyExoskeleton DeviceSpinal Cord InjuriesHumansOutcome Assessment, Health CareRecovery of Function

Identifiers

PMID40442492
PMCPMC12237692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.