Evidence map›Paper›PMID 40442475›Full record

ArticleOncogene2025

Macrophage activation determines muscle wasting in pancreatic cancer.

Chia-Jung Chang, Po-Hsien Huang, Szu-Ying Chen, Pei-Chia Su, Li-Yun Ding, Ya-Chin Hou, Miao-Neng Hung, Kuan-Lin Chen, Ya-Na Wu, Shang-Rung Wu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chia-Jung Chang *Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0000-0003-0977-8743
Po-Hsien Huang *Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. phhuang@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-2997-5181
Szu-Ying ChenInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0000-0002-3998-5922
Pei-Chia SuInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Li-Yun DingInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Ya-Chin HouDivision of General Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Miao-Neng HungDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Kuan-Lin ChenDepartment of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0000-0003-1387-1596
Ya-Na WuInternational Institute for Macromolecular Analysis and Nanomedicine Innovation, National Cheng Kung University, Tainan, Taiwan.
Shang-Rung WuInternational Institute for Macromolecular Analysis and Nanomedicine Innovation, National Cheng Kung University, Tainan, Taiwan.
Forn-Chia LinDivision of Radiation Oncology, Department of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Pei-Jung LuInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID http://orcid.org/0000-0002-8143-5668
Hsin-Yi WuInstrumentation Center, College of Science, National Taiwan University, Taipei, Taiwan.
Yu-Ju ChenInstitute of Chemistry, Academia Sinica, Taipei, Taiwan.ORCID http://orcid.org/0000-0002-3178-6697
Chih-Han ChangDepartment of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Chih-Peng ChangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Daw-Yang HwangNational Institute of Cancer Research, The National Health Research Institutes, Tainan, Taiwan.
Yi-Ching WangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan. ycw5798@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-7694-2067
Yan-Shen ShanDivision of General Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. ysshan@mail.ncku.edu.tw.ORCID http://orcid.org/0000-0002-2457-5189

Funding

National Cheng Kung University Hospital (NCKU Hospital) 10902063
6 · The paper itself

Abstract

The contribution of non-cancer tumoral microenvironment to cachexia is vastly unclear. Despite advances in understanding the signals involved in cancer cachexia progression, the exact time point of cachexia onset remains unpredictable. The transgenic Kras

Indexed as

CachexiaMacrophage ActivationMuscular AtrophyPancreatic NeoplasmsAnimalsHumansMacrophagesMiceMice, TransgenicMuscle, SkeletalTumor Microenvironment

Identifiers

PMID40442475
PMCPMC12318775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.